Biomolecules & Therapeutics
- 제7권3호
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- Pages.263-270
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- 1999
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- 1976-9148(pISSN)
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- 2005-4483(eISSN)
치로트로핀 유리 호르몬의 점막 투과 증진
Enhanced Transmucosal Permeation of Thyrotropin-releasing Hormone
초록
The in vitro permeation of thyrotropin-releasing hormone (TRH) through rabbit nasal, rectal and duodenal mucosae was studied in the absence and presence of an enzyme inhibitor and permeation enhancer. TRH in the donor and receptor solutions was assayed by HPLC. When thimerosal (TM, 0.5 mM) was added to the donor cell as an inhibitor, the permeation rate of TRH (200
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