A Study on Correlation of Entry into Hibernation and Epileptic Fit in Hibernators

동면돌입과 전간발작의 상호관련성에 관한 연구

  • 오영근 (연세대학교 문리대학 생명과학과) ;
  • 이서울 (연세대학교 의과대학 약리학교실)
  • Published : 1999.12.01


There are considerable interests in bat biology for investigating hibernation mechanism, in special regard to a hypothesis that the entry into hibernation is closely related with epileptic fit (petit mal) accompanying falling of body temperature, which is characterized by 3 spikes and wave/sec formation in electroencephalograph (EEG). This study was designed in order to examine physiological parameters (body temperature, heart rate, electroencephalograph and brain mapping) during normal patterns of the entry into hibernation and the hibernation period, and to observe effects of epileptogenic agents such as THC, Metrazol, and ILS on the physiological parameters. Based on the experimental results the entry into some hibernation seems to be related with epileptic fit, and therefore it is deduced that north temperate bats and the hamsters might be induced into hibernation by epileptogenic factors (pentylenetetrazol, THC and ILS etc) accompanying falling of body temperature and unique EEG and brain mapping.