Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Leucine Zipper as a Fine Tuner for the DNA Binding; Revisited with Molecular Dynamics Simulation of the Fos-Jun bZIP Complex

  • Published : 1999.11.20
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Abstract

Leucine zipper dynamically tunes the degree of bifurcation of the DNA binding segments in the basic region of the Fos-Jun bZIP complex. Molecular dynamics simulation indicated that site-specific mutagenesis of conserved leucine residues inside the leucine zipper domain caused the change of dynamic behavior of the basic region, and efficient DNA binding occurs only within a certain range of distance between the two DNA binding segments in the basic region. Distribution of α-helices in the hinge region is also suggested to influence the bifurcation of the DNA binding segments.

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References

  1. Science v.240 Landschultz, W. H.;Johnson, P. F.;McKnight, W. L.
  2. Nature v.336 Kouzarides, T.;Ziff, E.
  3. Science v.246 Vinson, C. R.;Sigler, P. B.;McKight, S. L.
  4. Nature v.340 Kouzarides, T.;Ziff, E.
  5. Science v.245 O'Shea, E. K.;Rutkowski, R.;Stafford Ⅲ, W. F.;Kim, P. S.
  6. Science v.243 Turner, R.;Tijan, R.
  7. Science v.249 O'Neil, K. T.;Hoess, R. H.;Degrado, W. F.
  8. Science v.243 Gentz, R.;Rauscher Ⅲ, F. J.;Abate, C.;Curran, T.
  9. Int. J. Cancer Suppl. v.4 Ransone, L. J.;Visvader, J.;Lamph, W. W.;Sassone-Corsi, P.;Verma, I. M.
  10. Nature v.373 Glover, J. N. M.;Harrison S. C.
  11. Nature v.338 Neuberg, M.;Schuermann, M.;Hunter, J. B.;Muller, R.
  12. Proteins v.4 Dauber-Osguthorpe, P.
  13. J. Chem. Phys. v.76 Swope, W. C.;Anderson, H. C.;Berens, P. H.;Wilson, K. R.
  14. J. Chem. Phys. v.81 Berendsen, H. J. C.;Postma, J. P. M.;van Gunsteren, W. F.;DiNola, A.;Haak, J. R.
  15. J. Phys. Chem. v.98 Smith, P. E.;Pettitt, B. M.
  16. Nature v.347 Patel, L.;Abate, C.;Curran, T.
  17. Nature v.347 Weiss, A. M.
  18. Proteins v.31 Tang, Y.;Nilsson, L.
  19. Science v.249 Talanian, R. V.;McKnight, C. J.;Kim, P. S.
  20. Nature v.307 Oi, V. T.
  21. Biopolymers v.22 Kabsch, W.;Sander, C.
  22. Protein and Peptide Letters v.6 Choi, Y.-H.;Yang, C.-H.;Kim, H.-W.;Jung, S.