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Synthesis and Evaluation of the Cholic Acid Derivatives with Multitrifluoroacetylbenzoyl (TFAB) Groups as Carbonate Ionophores

  • Published : 1999.02.20

Abstract

Several cholic acid derivatives containing 1-3 trifluoroacetylbenzoyl (TFAB) moieties were synthesized using selective acetylations, hydrolysis and/or oxidation of cholic acid derivatives and tested as receptors for a carbonate ion through solvent extraction method. The compounds having two and three TFAB moieties exhibited enhanced binding affinities toward a carbonate ion in comparison with those with one TFAB croup and the extent of complex formation also depended on the position of TFAB group attached.

Keywords

References

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