The Journal of Korean Society of Virology (대한바이러스학회지)

The Korean Society of Virology (대한바이러스학회)
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Effect of Bovine and Human Lactoferrin on MA 104 Cell Infected with Human Rotavirus

락토페린이 국내분리 유아 로타바이러스의 MA 104세포 감염에 미치는 영향

  • Cha, Kwang-Jong (School of Animal Life Science, College of Animal Husbandry, Konkuk University) ;
  • Yu, Dae-Yeul (Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Chong-Kee (Department of Microbiology, School of Medicine Catholic University of Taegu-Hyosung) ;
  • Yu, Jae-Hyeun (School of Animal Life Science, College of Animal Husbandry, Konkuk University)
  • 차광종 (건국대학교 축산대학 동물생명과학부) ;
  • 유대열 (KIST생명공학연구소) ;
  • 이종기 (대구효성가톨릭대학교 의과대학 미생물학교실) ;
  • 유제현 (건국대학교 축산대학 동물생명과학부)
  • Published : 1999.06.30
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Abstract

It has long been known that lactoferrin prevents human beings from infection of virus. To prove this activity of lactoferrin, we evaluated the activities of different lactoferrins to an isolate human rotavirus K-21. Bovine lactoferrin inhibited infection of K-21 to MA-104 cell at the concentration of $25.9\;{\mu}M$ whereas bovine hydrolysed lactoferrin prevented rotavirus infection at $103.8\;{\mu}M$. However human lactoferrin prevented infection of K-21 at the concentration of $217.5\;{\mu}M$. These data suggested that lactoferrin activity may be unaffected by the intestinal digestive enzymes and bovine lactoferrin is more active than human lactoferrin with respect to prevention of rotavirus infection.

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