Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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In Vitro Antibacterial Effect of a Mouthrinse Containing CPC (Cetylpyridinium Chloride), NaF and UDCA(ursodeoxycholic acid) against Major Periodontopathogens

Cetylpyridinium Chloride(CPC), NaF 및 Ursodeoxycholic acid(UDCA) 혼합물의 주요 치주병원균에 대한 in Vitro 항균효과

  • Kim, Chong-Kwan (Department of Periodontology, Research Institute for Periodontal Regeneration, Dental College, Yonsei University) ;
  • Choi, Bong-Kyu (Department of Oral Biology, Dental College, Yonsei University) ;
  • Yoo, Yun-Jung (Department of Oral Biology, Dental College, Yonsei University) ;
  • Kim, Sang-Nyun (LG Household and Health Care, R&D Institute) ;
  • Seok, Jae-Kyun (LG Household and Health Care, R&D Institute) ;
  • Kim, Moon-Moo (LG Household and Health Care, R&D Institute)
  • 김종관 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 최봉규 (연세대학교 치과대학 구강생물학교실) ;
  • 유윤정 (연세대학교 치과대학 구강생물학교실) ;
  • 김상년 (LG화학 생활과학연구소) ;
  • 석재균 (LG화학 생활과학연구소) ;
  • 김문무 (LG화학 생활과학연구소)
  • Published : 1999.06.30
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Abstract

The antibacterial efficacy of a mouthrinse(Denta Gargle) containing CPC(cetylpyridinium chloride), NaF and UDCA(ursodeoxycholic acid), on major periodontopathogens, was in vitro examined and compared with that of Listerine by a broth dilution method. The bacteria tested were Actinobacillus actinomycetemcomitans, Bacteroides forsythus, Fusobacterium nucleatum subsp. vincentii, Prevotella intermedia, Porphyromonas gingivalis and Treponema denticola. The growth of all the bacteria were completely inhibited by a 1-min exposure to the both mouthrinses. When diluted at 1:5 or more, all bacteria analyzed but P. intermedia were not inhibited by Listerine. In contrast, Denta Gargle showed highly increased maximum inhibitory dilutions(MID) against all periodontopathogens included in this study, with MIDs ranging from 5-fold(F. nucleatum) to 160-fold dilutions(P. intermedia). The MIDs against A. actinomycetemcomitans, B. forsythus, P. gingivalis and T. denticola. were 1:40, 1:80, 1:80 and 1:80, respectively.

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