Korean Journal of Veterinary Research (대한수의학회지)
- Volume 39 Issue 5
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- Pages.938-944
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- 1999
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- 2466-1384(pISSN)
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- 2466-1392(eISSN)
Effects of forskolin on secretion of insulin like growth factor-I in the perfused rat liver model
백서 간 관류모델에서 forskolin이 Insulin like growth factor-I의 분비에 미치는 효과
- Kang, Chang-won (Bio-Safety Research Institute, Chonbuk National University) ;
- Lee, Dae-yeol (Department of Pediatrics, Chonbuk National University Medical School) ;
- Lee, Ho-il (Bio-Safety Research Institute, Chonbuk National University)
- Received : 1999.02.08
- Published : 1999.10.25
Abstract
The insulin-like growth factor-I(IGF-I) is an important metabolic factor involved in cell growth and metabolism. Although secretion of IGF-I in rat liver is regulated by growth hormone, the effects of forskolin, adenylate cyclase activator, on secretion of IGF-I have not been reported. Therefore, a modified perfused rat liver model was used to investigate the regulatory effects of forskolin on IGF-I secretion in this experiment. The results were summerized as follows : 1. Modified perfused rat liver model was not changed to aspartate aminotransferase(AST), alanine aminotransferase(ALT) and lactic dehydrogenase(LDH) secretion in time. 2. The IGF-I secretion in hepatic cell was increased by forskolin(