Journal of Oral Medicine and Pain

Korean Academy of Orofacial Pain and Oral Medicine (대한안면통증구강내과학회)
권호 표지

The Effect of Pilocarpine-containing Chewing Gum on Anti-microbial Components in Whole Saliva of Xerostomic Patients

구강건조증 환자에서 필로카핀 함유 껌 사용에 따른 전타액내 항균성분의 변화

  • Park, Moon-Soo (Dept. of Oral Medicine and Oral Diagnosis, College of Dentistry Seoul, National University) ;
  • Lee, Sung-Woo (Dept. of Oral Medicine and Oral Diagnosis, College of Dentistry Seoul, National University) ;
  • Chung, Sung-Chang (Dept. of Oral Medicine and Oral Diagnosis, College of Dentistry Seoul, National University) ;
  • Kim, Young-Ku (Dept. of Oral Medicine and Oral Diagnosis, College of Dentistry Seoul, National University) ;
  • Yum, Kwang-Won (Dept. of Dental Anesthesiology, College of Dentistry, Seoul National University)
  • 박문수 (서울대학교 치과대학 구강내과.진단학 교실) ;
  • 이승우 (서울대학교 치과대학 구강내과.진단학 교실) ;
  • 정성창 (서울대학교 치과대학 구강내과.진단학 교실) ;
  • 김영구 (서울대학교 치과대학 구강내과.진단학 교실) ;
  • 염광원 (서울대학교 치과대학 치과마취학교실)
  • Published : 1999.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study was to investigate the effect of pilocarpine containing chewing gum on anti-microbial components in whole saliva of xerostomic patients, The objective xerostomic patients were instructed to use 5mg-pilocarpine containing chewing gum for 20minutes three times per day, and the author measured the flow rates of unstimulated whole saliva and stimulated whole saliva at the beginning the treatment, 1,2,3, and 4 weeks after. The concentration and flow rate of anti-microbial components in whole saliva were quantitated by enzyme-linked immunosorbent assay(ELISA). The obtained results were as follows: 1. There were significant increase in the unstimulated and stimulated whole salivary flow rate after using pilocarpine-containing chewing gum in xerostomic patients. 2. The concentrations of IgA in the unstimulated and stimulated whole saliva showed increasing pattern but, no significant changes, arid the flow rates of IgA in the unstimulated and stimulated whole saliva showed significant increase after using pilocarpine-containing chewing gum in xerostomic patients. 3. The concentrations of IgM in the unstimulated and stimulated whole saliva showed increasing pattern but, no significant changes, and the flow rates of IgM in the unstimulated and stimulated whole saliva showed significant increase after using pilocarpine-containing chewing gum in xerostomic patients. 4. The concentrations of lactoferrin in the unstimulated and stimulated whole saliva showed no significant changes, and the flow rates of lactoferrin in the unstimulated and stimulated whole saliva showed significant increase after using pilocarpine-containing chewing gum in xerostomic patients. 5. The concentrations of lysozyme in the unstimulated and stimulated whole saliva showed no significant changes, and the flow rates of lysozyme in the unstimulated whole saliva showed significant increase, but in stimulated whole saliva showed no significant changes after using pilocarpine-containing chewing gum in xerostomic patients.

Keywords

Acknowledgement

Supported by : 서울대학교병원