The Journal of Dong Guk Oriental Medicine (동국한의학연구소논문집)

Research Institute of Oriental Medicine (동국대학교 한의학연구소)
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Study on the effect of Buthus martensi Karsch extract on thrombosis and brian damage

전갈(全蝎) 추출물(抽出物)이 혈전증(血栓症), 전뇌허혈(全腦虛血) 및 뇌세포독성(腦細胞毒性)에 미치는 영향(影響)

  • Baek, Myung-Hyun (Dept. of Pathology, College of Oriental Medicine, Taejon Univ.) ;
  • Hwang, Yong-Geun (Dept. of Internal Medicine, College of Oriental Medicine, Doogguk Univ.) ;
  • Jeong, Ji-Cheon (Dept. of Internal Medicine, College of Oriental Medicine, Doogguk Univ.) ;
  • Kang, Jeong-Jun (Dept. of Internal Medicine, Oriental Medicine, Hospital, Hanseo Univ.) ;
  • Kim, Sung-Hoon (Kyunghee University Graduated School of East-West Medical Science)
  • 백명현 (대전대학교 한의과대학 병리학교실) ;
  • 황영근 (동국대학교 한의과대학 내과학교실) ;
  • 정지천 (동국대학교 한의과대학 내과학교실) ;
  • 강정준 (한서대학교 한방병원 내과) ;
  • 김성훈 (경희대학교 동서의학 대학원)
  • Published : 1999.08.31
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Abstract

This following is effect of Buthus martensi Karsch(BMK) extract on dextran-thrombus model, KCN-induced coma, cytotoxicity of brain etc. BMK extract significantly increased number of platelet and fibrogen and significantly shortened the prothrombin time as compared with control group treated with dextran. BMK extract didn't affect the changes of hematocrit as compared with control group treated with dextran. BMK extract induced a significant inhibition of human platelet aggregation induced by thrombin and ADP but did not affect human platelet aggregation induced by collagen. BMK extract showed a protective effect on pulmonary thrombosis induced by collagen and epinephrine. BMK extract prolonged the duration of KCN-induced coma and showed a protective effect on cytotoxicity of PC12 cells induced by amyloid ${\beta}$ protein(25-35) in a dose dependent manner. These results suggested that BMK extract might be usefully applied for prevention and treatment of thrombosis and brain damage.

본 실험은 전갈 추출물이 어혈병태 모델과 KCN으로 유발된 전뇌허혈, 뇌세포독성 등에 미치는 영향을 관찰하였다. 전갈은 Dextran에 의해 유도된 혈전으로 감소된 혈소판수, fibrinogen량, hemocrit치를 유의성 있게 증가시키고, 증가된 prothrombin time을 유의성 있게 단축시켰다. 전갈은 thrombin과 ADP에 의해 유도된 혈소판 응집을 억제하였으나 collagen에 의해 유도된 혈소판 응집에는 저해효과를 나타내지 않았다. 또한 collagen과 epinephrine에 의해 유도된 pulmonary embolism에 대하여 보호 효과를 나타내었다. 전갈은 KCN에 의한 전뇌허혈 유발 실험에서 혼수시간을 유의성 있게 단축시켰고, Amyloid ${\beta}$ protein(25-35)에 의해 유도된 PC12 세포의 독성에 대하여 보호효과를 나타내었다.

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