Journal of Ginseng Research
- Volume 23 Issue 1 Serial No. 53
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- Pages.38-43
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- 1999
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- 1226-8453(pISSN)
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- 2093-4947(eISSN)
Effect of Spinally Administered Ginseng Total Saponin on Capsaicin-Induced Pain and Excitatory Amino Acids-Induced Nociceptive Responses
- Nah Jin-Ju (Department of Physiology, College of Veterinary Medicine) ;
- Choi Seok (Department of Physiology, College of Veterinary Medicine) ;
- Kim Yoon-Hee (Department of Physiology, College of Veterinary Medicine) ;
- Kim Seok-Chang (Korea Ginseng and Tobacco Research Institute) ;
- Nam Ki-Yeul (Korea Ginseng and Tobacco Research Institute) ;
- Kim Jong-Keun (Department of Pharmacology College of Medicine, Chonnam National University) ;
- Nah Seung-Yeol (Department of Physiology, College of Veterinary Medicine)
- Published : 1999.03.01
Abstract
Ginseng total saponins (ginsenosides) are biologically active main ingredients of Panax ginseng. In present study, we have investigated whether pretreatment of ginsenosides inhibited capsaicin-induced pain at the spinal level, in the view that capsaicin causes substance P (SP) release from primary afferents. Ginsenosides relieved capsaicin-induced pain in a dose-dependent manner. The
진세노사이드(ginseng total saponin)는 인삼의 주요 약리학적 성분이다. 본 연구는 척수강내로 투여된 진세노사이드가 캡사이신에 의하여 유도된 통증을 억제하는가를 연구하였다. 진세노사이드의 척수강내 전투여는 캡사이신에 의하여 유도되는 통증을 투여 용량에 의존적으로 억제하였다. 통증 억제 효과를 나타내는