Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Effects of Several Medicinal Plants on the Activity of GABA-metabolizing Enzymes

수종 생약재의 GABA 대사 관련 효소의 활성에 미치는 영향

  • Ahn, Eun-Mi (Department of Life Sciences and Institute of Life Sciences, Kyung Hee University) ;
  • Han, Jae-Taek (Department of Life Sciences and Institute of Life Sciences, Kyung Hee University) ;
  • Park, Jin-Kyu (Korea Ginseng & Tobacco Research Institute) ;
  • Cho, Sung-Woo (University of Ulsan College of Medicine, Department of Biochemistry) ;
  • Jeon, Seong-Gyu (Department of Genetic Engineering, Division of Life Science) ;
  • Bahn, Jae-Hoon (Department of Genetic Engineering, Division of Life Science) ;
  • Sun, Hyun-Jung (Department of Genetic Engineering, Division of Life Science) ;
  • Choi, Soo-Young (Department of Genetic Engineering, Division of Life Science) ;
  • Baek, Nam-In (Department of Life Sciences and Institute of Life Sciences, Kyung Hee University)
  • 안은미 (경희대학교 생명과학부 및 생명과학연구원) ;
  • 한재택 (경희대학교 생명과학부 및 생명과학연구원) ;
  • 박진규 (한국인삼연초연구원) ;
  • 조성우 (울산대학교 의과대학 생화학교실) ;
  • 전성규 (한림대학교 생명과학부 유전공학과) ;
  • 반재훈 (한림대학교 생명과학부 유전공학과) ;
  • 선현정 (한림대학교 생명과학부 유전공학과) ;
  • 최수영 (한림대학교 생명과학부 유전공학과) ;
  • 백남인 (경희대학교 생명과학부 및 생명과학연구원)
  • Published : 2000.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

The effect of seventy kinds of medicinal plants on the activities of GABA-metabolizing enzymes as glutamate dehydrogenase I (GDH I), glutamate dehydrogenase II (GDH II), GABA transaminase (GABA-T), succinic semialdehyde dehydrogenase (SSADH) and succinic semialdehyde reductase (SSAR) were estimated. The following plants extracts from Acori graminei Rhizoma, Longnae Arillus, Gastrodiae Herba, Lycii Fructus, Ligusticum officinale, Ferula assafoetida, Corydalis Tuber, Eucommiae Cortex, Zizyphi spinosi Semen activated the activity of GDH I to more than 35%, and the following ones from Visci Ramulus, Ligusticum officinale, Myristicae Semen, Ferulae Resina, Scolopendrae Corpus, Corydalis Tuber, Eucommiae Cortex, Zizyphi spinosi Semen did that of GDH II. The plant extracts from Cynanchi Radix, Astragali Semen, Angelicae dahuricae Radix, Biotae orientalis Folium, Uncariae Ramulus et Uncus, Polygalae Radix, Cynomorii Herba inhibited that of GABA-T to 35% and over, and the following ones from Hyoscyamus niger, Cynanchi Radix, Acori graminei, Caesalpiniae Lignum, Cannabis Semen, Sedum aizoon, Sedum kamtschaticum, Schisandrae Fructus, Lilii Bulbus, Biotae orientalis Folium, Uncariae Ramulus et Uncus, Myristicae Semen, Akebiae Fructus, Cynomorii Herba, Buddleiae Flos, Mucunae Caulis, Zizyphi Fructus, Paeoniae Radix rubra did that of SSADH to 70% and over; the following ones from, Caesalpiniae Lignum, Sedum kamtschaticum, Schisandrae Fructus, Astragali Semen, Angelicae dahuricae Radix, Dioscorea nipponica, Myristicae Semen, Akebiae Fructus, Cynomorii Herba, Scutellariae Radix did that of SSAR.

Keywords