Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

The Anti-inflammatory and Analgesic Actions of the fractions from Pulsatilla koreana Root Extract

백두옹엑스 분획물의 소염진통작용

  • Cheon, Seon-Ah (College of Pharmacy, Dongduk Women's University) ;
  • Choi, Byung-Kee (College of Pharmacy, Dongduk Women's University) ;
  • Jeong, Choon-Sik (College of Pharmacy, Duksung Women's University) ;
  • Li, Da-Wei (Natural Products Research Institute, Seoul National University) ;
  • Lee, Eun-Bang (Natural Products Research Institute, Seoul National University)
  • 천선아 (동덕여자대학교 약학대학) ;
  • 최병기 (동덕여자대학교 약학대학) ;
  • 정춘식 (덕성여자대학교 약학대학) ;
  • 이대위 (서울대학교 천연물과학연구소) ;
  • 이은방 (서울대학교 천연물과학연구소)
  • Published : 2000.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

From our previous report, the water extract of Pulsatilla koreana root was found to have potent anti-inflammatory and analgesic actions in intravenous administration in animals. Among chloroform, ethyl acetate, butanol and water fractions which were obtained through successive fractionation of the extract, only the water fraction was found to have the antiinflammatory and analgesic actions. The fraction did not affect normal body temperature at the effective doses in mice and showed low acute toxicity of which $LD_{50}$ was less than 500 mg/kg i.v. in mice. It is interesting that its anti-inflammatory action might be attributed in part to inhibition of cyclooxygenase-1 and -2.

Keywords