대한약침학회지 (Journal of Pharmacopuncture)

  • 제3권2호
  • /
  • Pages.191-212
  • /
  • 2000
  • /
  • 2093-6966(pISSN)
  • /
  • 2234-6856(eISSN)
대한약침학회 (KOREAN PHARMACOPUNCTURE INSTITUTE)
권호 표지
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자하거약침자극(紫河車藥鍼刺戟)이 HgCI2로 손상(損傷)된 흰쥐의 신장(腎臟) 및 간장(肝臟)에 미치는 영향(影響)

Effects of Hominis Placenta Aqua-acupuncture on Kidney and Liver Intoxicated by HgCI2 in Rats

  • Lee, Sang-Keel (Dept. of Acupuncture & Moxibustion. College of Oriental Medicine, Kyung Hee University) ;
  • Seo, Jung-Chul (Dept. of Acupuncture & Moxibustion. College of Oriental Medicine, Kyung Hee University) ;
  • Choi, Do-Yong (Dept. of Acupuncture & Moxibustion. College of Oriental Medicine, Kyung Hee University) ;
  • Park, Dong-Suk (Dept. of Acupuncture & Moxibustion. College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Yun-Hoo (Dept. of Acupuncture & Moxibustion. College of Oriental Medicine, Kyung Hee University) ;
  • Kang, Sung-Keel (Dept. of Acupuncture & Moxibustion. College of Oriental Medicine, Kyung Hee University)
  • 발행 : 2000.12.30
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초록

Objective: This study was perfomled to examine the therapeutic effect of aqua-acupuncture solution of Hominis Placenta(HP) on kidney and liver intoxicated by $HgCI_2$ in rats. Methods: $10\%$ and $25\%$ HP aqua-acupuncture were carried out everyday for 8 days on corresponding bilateral loci of Shinsu(BL23) and Kansu(BL18), respectively, after mercuric chloride intoxication in rats. Thereafter BUN, creatinine, GOT, GPT, ALP, ${\gamma}$-GT, albumin and total bilirubin were measured before intoxication, and at the 4th and the 8th experimental day. Histopathological and immunochemical observation were also carried out. Results: 1. It showed significant decreases of BUN in the group of $10\%$ HP aqua-acupuncture into Shinsu on the 4th experimental day as compared with the control group. 2. It showed significant decreases of creatinine in the group of $10\%$ HP aqua-acupuncture into Shinsu on the 4th and the 8th experimental days as compared with the control group. 3. There were not any significant changes of GOT, GPT, ALP,${\gamma}$-GT, albumin and total bilirubin in the HP aqua-acupuncture groups compared with the control group. 4. By the histopathological observations on kidney under a light microscope, alt the $10\%$ and $25\%$ HP aqua-acupuncture into Shinsu showed the preventive effect on tubulo-interstitial necrosis and muItifocal calcification in tubular lumen respectively compared with the control group. 5. By the histopathological observations on liver under a light mIcroscope, the groups $10\%$ and $25\%$ HP aqua--acupuncture into Kansu did not show any significant changes in the liver compared with the control group. 6. By the immunochemical analysis of heat shock protein(hsp) and glucose-regulated protein(grp) in rat renal cortex, the expressions of hsp70 and grp78 were decreased in the $10\%$ and $25\%$ HP aqua-acupuncture into Shinsu respectively compared with the control group. Conclusion: These results suggest that Hominis Placenta aqua-acupuncture have an effect on prevention and protection of renal intoxication by $HgCI_2$ in rats.

키워드

참고문헌

  1. 毒物學 高錫太(外)
  2. 臨床 腎系學硏究 杜鎬京
  3. 分子細胞生物學 박상대(외)
  4. 漢方婦人科學 宋炳基
  5. 醫學正傳 盧搏
  6. 임상병리파일 이귀녕;이종순
  7. 本草學 李尙仁
  8. 本草綱目(校正本) 李時珍
  9. 毒性病理學 伊東信行
  10. 肝系內科學 全國韓醫科大學 肝系內科學敎授一同
  11. 鍼灸學 全國韓醫科大學 鍼灸經穴學校室
  12. 組織學 정일천
  13. 基礎毒性學 조명행;김복환
  14. 分子生物學 주성필
  15. 證類本草 陣嘉謨
  16. 毒性學 許仁會(外)
  17. 東醫寶鑑 許浚
  18. 證脈ㆍ方藥合編 黃度淵
  19. 慶熙韓醫大論文集 v.5 大戟水鍼이 鎭痛 및 水銀中毒에 미치는 影響에 關한 硏究 姜成吉;崔容泰
  20. 慶熙大論文集 v.4 八正散이 鹽化第2水銀 및 四鹽化炭素에 依한 白鼠腎損傷에 미치는 影響 金德坤;朴憲在
  21. 大韓韓醫學會誌 v.4 no.1 淸肺瀉肝湯이 昇汞中毒家兎의 肝 및 腎臟機能에 미치는 影響 金東圭;柳基遠
  22. 원광대한의대논문집 v.8 no.1 牛黃淸心元의 長期投與가 血中 水銀 濃度와 血球 및 肝, 腎機能에 미치는 影響 김동웅
  23. 동양의학 v.7 no.3 利腎淸肝健脾湯이 四鹽化炭素 및 昇汞中毒白鼠의 肝 · 腎機能에 미치는 影響 金來元
  24. 家庭醫 v.9 no.6 慢性 水銀中毒 事例 김명성(外)
  25. 동의대한의대논문집 v.2 no.1 加味行滯湯 合 六味地黃湯이 水銀(Hg)에 依한 家兎 肝組織損傷에 미치는 影響 김원일;김우환
  26. 大韓韓醫學會誌 v.14 no.1 靈砂法製 回數에 따른 흰쥐의 血淸中 水銀濃度 및 肝腎機能에 미치는 影響 남상경;예경욱
  27. 大韓鍼灸科學會誌 v.16 no.4 漁腥草藥鍼刺戟이 $HgCl_2$로 損傷된 흰쥐의 腎臟 및 肝에 미치는 影響 柳忠烈;成賢濟;金容奭;崔道永;高炯均;朴東錫;姜成吉
  28. 大韓鍼灸科學會誌 v.16 no.3 腎臟에서 水銀에 依한 유기양이온 이동계의 障碍에 對한 紅花子藥鍼液의 效果 이경미;장경전;송춘호;안창범
  29. 大韓鍼灸科學會誌 v.16 no.3 胡桃藥鍼液이 水銀(Hg)에 依한 肝組織 損傷에 미치는 影響 이경태;송춘호
  30. 大韓鍼灸科學會誌 v.17 no.1 紫河車 藥鍼製劑에 對한 考察 李相吉;李裁東;高炯均;朴東錫;李潤浩;姜成吉
  31. 大韓鍼灸科學會誌 v.16 no.4 紫河車 煎湯液이 卵巢摘出로 誘發된 흰쥐의 骨多孔症에 미치는 影響 李相龍;金永安
  32. 大韓韓醫學會誌 v.19 no.1 紫河車ㆍ鹿茸ㆍ紅花子 藥鍼液이 卵巢摘出로 骨多孔症을 誘導한 흰쥐에 미치는 影響 장수진;이창현;육태환
  33. 大韓韓醫學會誌 v.2 no.5 紫河車에 對한 考察 장종범
  34. 釜山醫大學術誌 v.36 no.1 四鹽化炭素 急性中毒 家兎肝의 再生時 Hepatocyte Growth Factor의 影響에 關한 實驗的 硏究 정수철;문상은
  35. 原典醫史學會誌 v.15 no.1 紅花子藥鍼이 水銀中毒에 依한 家兎의 急性腎不全에 미치는 影響 조민수;안창범
  36. 大韓鍼灸學會誌 v.9 no.1 蔘歸茸湯水鍼이 $HgCl_2$에 依한 白鼠腎不全에 미치는 影響 趙修苑;李鳴鐘;金甲成;安春浩;安昌範
  37. 大韓鍼灸學會誌 v.9 no.1 艾灸가 $HgCl_2$에 依한 白鼠腎不全에 미치는 影響 趙東漢;林鐘國
  38. 원광대한의대논문집 v.7 no.1 土茯笭을 利用한 Rats의 水銀中毒 解毒에 關한 硏究 최광순;이기남
  39. 婦人科學會誌 v.12 no.2 紫河車가 卵巢摘出로 骨多孔症을 誘發한 흰쥐에 미치는 影響 최금호;홍성은;서용주;박병렬
  40. 古今醫鑑 공信
  41. 萬病醫藥顧問(急救科) 陸靑節
  42. 本草求眞 黃宮繡
  43. Genes & Development v.6 The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression Abrabaya, K.;Myers, M.P.;Murphy, S.P.;Morimoto, R.I. https://doi.org/10.1101/gad.6.7.1153
  44. Rhinology & Laryngology v.104 no.3 Evidence linking the 68 kilodalton antigen identified in progressive sensorineural hearing loss patient sera with heat shock protein 70, Annals of Otology Billings, P.B.;Keithley, E.M.;Harris, J.P. https://doi.org/10.1177/000348949510400302
  45. American Journal of Industrial Medicine v.19 Effects of elemental mercury exposure at a thermometer plant Ehreberg, R.L.(et al.) https://doi.org/10.1002/ajim.4700190407
  46. Toxicological Sciences v.53 Mercury induces regional and cell-specific protein expression in rat kidney Goering, L.P.(et al.) https://doi.org/10.1093/toxsci/53.2.447
  47. Journal of Biological Chemistry v.275 no.42 Hsp90 chaperone activity requires the full-length protein and interaction among its multiple domains Johnson, D.B.(et al.) https://doi.org/10.1074/jbc.M005195200
  48. Korean Journal of Zoology v.38 Biochemical characterization of glucose-regulated proteins, grp94 and BiP/grp78 Kang, H.S.;Kim, C.R.;Kim, B.G.;Hah, J.C.;Kim, H.D.
  49. Korean Journal of Microbiology v.29 no.1 Synthesis and thermotolerance of heat shock proteins in campylobacter jejuni Kim, C.K.;Kim, H.O.;Lee, K.J.
  50. Laryngoscope v.107 Comparison of anti-heat shock protein 70(anti-hsp-70) and anti-68-KD inner ear protein in the sera of patients with Meniere's disease Shin, S.;Billings, P.B.;Keithley, E.M.;Harris, J.P. https://doi.org/10.1097/00005537-199702000-00015
  51. Exp. Mol. Patal. v.35 Metabolic studies of $HgCl_2$-induced acute renal failure in the rat Trifillis, A.L.;Kahng, M.W.;Trump, B.F. https://doi.org/10.1016/0014-4800(81)90003-4

피인용 문헌

  1. A Pilot Study on Single-dose Toxicity Testing of Hominis placenta Pharmacopuncture in Sprague-Dawley Rats vol.18, pp.2, 2015, https://doi.org/10.3831/KPI.2015.18.015