Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지

The Effects of Moxi tar on iNOS Synthase in RAW 264.7 Cell

구진(灸津)(Moxi tar)이 면역세포(免疫細胞)에서 iNOS합성에 미치는 영향(影響)

  • Ahn Sung-Hun (Dept. of AM-Meridian & Pointology, College of Oriental Medicine, Wonkwang University) ;
  • Koo Sung-Tae (Dept. of AM-Meridian & Pointology, College of Oriental Medicine, Wonkwang University) ;
  • Do Jin-Woo (AM-Meridian & Pointology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Jong-Sung (Dept. of AM-Meridian & Pointology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Kwang-Soo (Dept. of AM-Meridian & Pointology, College of Oriental Medicine, Wonkwang University) ;
  • Yang Beom-Sik (Dept. of AM-Meridian & Pointology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Kyung-Sik (Dept. of AM-Meridian & Pointology, College of Oriental Medicine, Wonkwang University) ;
  • Sohn In-Chul (Dept. of AM-Meridian & Pointology, College of Oriental Medicine, Wonkwang University)
  • 안성훈 (원광대학교 한의과대학 경혈학교실) ;
  • 구성태 (원광대학교 한의과대학 경혈학교실) ;
  • 도진우 (원광대학교 한의과대학 경혈학교실) ;
  • 김종성 (원광대학교 한의과대학 경혈학교실) ;
  • 김광수 (원광대학교 한의과대학 경혈학교실) ;
  • 양범식 (원광대학교 한의과대학 경혈학교실) ;
  • 김경식 (원광대학교 한의과대학 경혈학교실) ;
  • 손인철 (원광대학교 한의과대학 경혈학교실)
  • Published : 2000.03.27
Download PDF
⟨ Previous Next ⟩

Abstract

This study was produced to examine the effects of moxibution that had been played a role of traditional oriental medical treatment on disease. We used LPS and INF-gamma in RAW 264.7 cell line to produce Nitric Oxide(NO). And results was that Moxi tar decreased NO in activated RAW 264.7 cell by LPS and INF-gamma significantly, which was decreasing Nitric Oxide Synthase. So we proposed that Moxi tar had anti-inflammation and anti-cytotoxity in RAW 264.7 cell by decreasing Nitric Oxide Synthase.

Keywords

References

  1. 원색임상본초학 신민교
  2. 현대침구학 성낙기
  3. 黃帝內經, 素問靈樞 張馬合註 張志聰;馬蒔
  4. 본초학 전국한의과대학본초학교수(공편저)
  5. 신편중약대사전
  6. Chem. Eng. News The surprising life of nitric oxide Feldman, P. L.;Griffith, O. W.;Sheuhr. D. J.
  7. Mechanisms of Vasodilatation Biochemical and pharmacological properties of endothelium-derived relaxing factor and its similarity to nitric oxide radical Ignarro, L. J.;Byrrns, R. E.;Wood, K. S.;P. M. Vanhoutte(ed.)
  8. Trends Neurosci. v.14 Glutamate, nitric oxide and cell-cell signlling in the nervous system J. Garthwaite
  9. Eur. J. Pharmacol. v.172 NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices J. Garthwaite;G. Garthwaite;R.M.J, Palmer;S. Mondaca
  10. 동양의학 v.2 no.1 灸治療의 文獻的 觀察 林鍾國
  11. 동양의학 v.2 no.3 艾灸의 生體反應에 관한 文獻的 考察 林鍾國
  12. 중의임상 v.4 關元兪 등에 대한 刺鍼이 부신피질의 기능에 주는 영향 華延會
  13. 全日本灸學會雜誌 v.37 no.3 구およびモグサし연소생성물による우췌치험2증예보고 西谷郁子
  14. 全日本灸學會雜誌 v.38 no.1 艾の燃燒生成物に含まれる抗酸化作用物質について 西谷郁子;植田伸夫
  15. 鍼灸資生經 王執中
  16. 神灸經論 吳亦鼎
  17. 大田大學校 韓醫學硏究所 論文集 v.5 no.2 艾炷의 刺戟量에 關한 文獻的 考察 趙命來
  18. 國譯編註醫學入門 이천
  19. 원광한의대 논문집 v.1 관원혈 애구 및 Laser 광선침 자극이 자발성 고혈압 흰쥐의 혈압에 미치는 영향 손인철;이호섭;배문홍
  20. 동양의학 v.6 애구의 용량이 혈청중산소활성에 미치는 영향 金庚植
  21. 애구가 실험적 고혈압 백서의 혈압, 혈장 renin 활성도 및 catecholamine농도에 미치는 영향 이준무
  22. 대한한의학회지 v.14 no.1 애구의 연소특서에 관한 실험적 연구(Ⅰ) 박영배;강성길;김갑성;안창범;오환섭;허웅
  23. 대한한의학회지 v.16 no.1 애주의 형태별 연소특성에 대한 연구 박영배;강성길;김창환;고동균;오환섭;허웅
  24. Chem. Eng. News. The surprising life of nitric oxide Feldman, P. L.;Griffith, O. W.;Sheuhr. D. J.
  25. Proc. Natl Acad. Sci. v.87 The NO hypothesis ; Possible effects of a short-lived, rapidly diffusible signal in the development and function of the nervous system Gally, J. A.;Montague, P. R.;Reeke, G. N. Jr.;Edelman, G. M.
  26. Pharmacol. Rev. v.43 Nitric oxide ; Physiology, pathophysiology, and pharmacology Moncada, S.;Palmer, R. M. J.;Higgs, E. A.
  27. Nature v.336 Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain Garthwaite, J.;Charles, S. L.;Chess-Williams, R.
  28. Proc. Natl. Acad. Sci. v.88 Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures Dawson, V. L.;Dawson, T. M.;London, E. D.;Bredt, D. S.;Synder, S. H.
  29. J. Neurosci. v.8 Vulnerability of cultured cortical neurons to damage by endotoxins ; Differential susceptibility of neurons containing NADPH-diaphorase Koh, J. Y.;Choi, D. W.
  30. J. Pharmacol. Exp. Ther. v.237 Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein ; Stimulation by acetylcholine, bradykinin and arachidonic acid Ignarro, L. J.;Harbison, R. G.;Wood, K. S.;Kadowitz, P. J.
  31. J. Biol. Chem. v.259 Guanylate cyclase from bovine lung ; Evidence that enzyme activation by phenylhydrazine is mediated by ironphenyl hemoprotein complexes Ignarro, L. J.;Wood, K. S.;Ballot, B.;Wolin, M. S.
  32. Circ. Res. v.61 Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacological and chemical properties that are identical to those for nitric oxide radical Ignarro, L. J.;Byrns, R. E.;Buga, G. M.;Wood, K. S.
  33. Biochem. Biophys. Res. Commun. v.176 $N^G$-Hydroxy-L-arginine ; A novel arginine analog capable of causing vasorelaxation in bovine inreapulmonary artery Wallace, G. C.;Gulati, P.;Fukuto, J. M.
  34. Proc. Natl. Acad. Sci. v.87 $N^G$-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein Gole, M. E.;Wood, K. S.;Byrns, R. E.;Fukuto, J. M.;Ignarro, L. J.
  35. Biochem. Biophys. Res. Commun. v.168 $N^G$-amino-L-arginine ; A new potent antagonist of L-arginine-mediated endothelium-dependent relaxation Fukuto, J. M.;Wood, K. S.;Byrns, R. E.;Ignarro, L. J.
  36. Science v.235 Macrophage cytotoxity ; Role for L-arginine deiminase and imino nitrogen oxidation to nitrite Hibbs, J. B.;Taintor, R. R.;Vavrin, Z.
  37. Proc. Natl. Acad. Sci. v.84 Macrophage synthesis of nitrite, nitrate, and N-ni-trosamines ; Precursors and role of the respiratory burst Iyengar, R.;Stuehr, D. J.;Marletta, M. A.
  38. Nature v.333 Vascular endothelial cells synthesize nitric oxide from L-arginine Palmer, R. M. J.;Ashton, D. S.;Moncada, S.
  39. Biochem. Biophys. Res. Cimmun. v.153 L-Arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation Palmer, R. M. J.;Rees, D. D.;Ashton, D. S.;Moncada, S.
  40. Proc. Natl. Acad. Sci. v.86 Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum Bredt, D. S.;Snyder, S. H.
  41. Proc. Natl. Acad. Sci. v.87 Isolation of nitric oxide synthetase, a calmodulin requiring enzyme Bredt, D. S.;Snyder, S. H.
  42. Hypertension v.4 Calcium and endothelium mediated vascular smooth muscle relaxation in rabbit aorta Singer, H. A.;Peach, M. J.
  43. J. Pharmacol. Exp. Ther. v.226 Endothelium dependent relaxation of rabbit aorta. Ⅰ. Relaxation stimulated by arachidonic acid Singer, H. A.;Peach, M. J.
  44. Blood Vessels v.22 The release of endothelium-derived relaxing factor is calcium-dependent Long, C. J.;Stone, T. W.
  45. Clin. Exp. Immunol. v.93 Production of IL-1${\beta}$ and IL-1${\beta}$ receptor antagonist and pathological significance in lipopolysaccharide-in duced arthitis in rabbits A. Matsukawa;S. Ohkawara;T. Maeda;K. Takagi;M. Yoshinaga
  46. Nature v.336 Endotheliumderived relaxing factor release on activation of NMDA receptors suggests a role as intercellular messanger in the brain Garthwaite, J.;Chales, S.L.;Chess-Williams, R.
  47. Progr. Neurobiol. v.42 Nitric oxide ; a radical neurotransmitter in the central nervous system Vincent, S.R.
  48. Biochim. Biophys. Acta. v.1181 EPR spin-trapping study of nitric-oxide formation during bilateral carotid occlusion in the rat Sato, S.;Tominaga, T.;Ohnishi, S.T.
  49. Brain Res. v.614 Potentiation of nitric oxide formation following bilateral carotid occlusion and focal cerebral-ischemia in the rat. In vivo detection of nitric oxide radial by electron-paramagnetic-resorance spin trapping Tominaga, T.;Sato, S.;Ohnishi, S.T.
  50. 한방물리요법과학회지 v.5 no.1 白虎湯 과 白虎加 桂枝湯이 류마토이드 관절염 및 Human monocyte의 IL-8에 미치는 영향 류경주;신현대;정석희;이종수;김성수
  51. 한방물리요법과학회지 v.5 no.1 竝祛湯이 류마토이드 관절염 및 Human Monocyte의 IL-8에 미치는 영향 이충원;이종수;정석희;김성수;신현대