A study of osteonectin expression patterns in BAPN-induced cleft palate formed rats

BAPN으로 유도된 구개파열 백서의 osteonectin발현 양상에 대한 연구

  • Tae, Ki-Chul (Department of Orthodontics and Oral Pathology, School of Dentistry, Wonkwang Dental Institute, Wonkwang University) ;
  • Kim, En-Chel (Department of Orthodontics and Oral Pathology, School of Dentistry, Wonkwang University) ;
  • Lee, Sun-Kyeong (Department of Orthodontics and Oral Pathology, School of Dentistry, Wonkwang University)
  • 태기출 (원광대학교 치과대학 교정학 교실, 원광치의학연구소) ;
  • 김은철 (원광대학교 치과대학 구강병리학 교실) ;
  • 이선경 (원광대학교 치과대학 구강병리학 교실)
  • Published : 2000.08.01

Abstract

The purpose of this study was to investigate osteonectin expression patterns in cleft palate compare to normal palate rats. We used 4 pregnant rats, and beta-aminoproprionitrile was oral dose to rat according to 1g/kg body weight at gestation days 13 to induce cleft palate. Total 6 fetus was got with cleft formed, then 3 fetus was used for immunohistostain and 3 fetus was used for western blot analysis. Expression patterns of osteonectin in mesenchymal cells of cleft palate was more dilute to mesenchymal cells of normal palate with immnunohistostain, and width and length of band of maxilla in cleft palate was more thin than maxilla of normal palate with western blot study.