Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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New Polyene Macrolide Antibiotics from Streptomyces sp. M90025

  • Seo, Young-Wan (Marine Natural Products Laboratory, Korea Ocean Research & Development Institute) ;
  • Cho, Ki-Woong (Marine Natural Products Laboratory, Korea Ocean Research & Development Institute) ;
  • Lee, Hyi-Seung (Marine Natural Products Laboratory, Korea Ocean Research & Development Institute) ;
  • Yoon, Tae-Mi (Marine Natural Products Laboratory, Korea Ocean Research & Development Institute) ;
  • Shin, Jong-Heon (Marine Natural Products Laboratory, Korea Ocean Research & Development Institute)
  • Published : 2000.04.01
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Abstract

Three polyene macrolide antibiotics including two new compounds were isolated from the culture mycelia of a Streptomyces species. The structures of these metabollites were determined as elizabethin, a previously reported 28-membered macrolide and two analohs, using combined spectroscopic methods. These compounds exhibited antifungal activity and cytotoxicity against a juman leukemia cell.

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References

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