Journal of Embryo Transfer (한국수정란이식학회지)

The Korean Society of Embryo Transfer (한국수정란이식학회)
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Effects of Administration of Agyoju and Mokhyang on Ovarian Function and Pregnancy Outcomes

아교주와 목향의 투약이 생쥐의 난소반응과 임신에 미치는 영향

  • Chung, H. M. (Infertility Medical Center of Cha General Hospital, Pochon CHA University) ;
  • Lee, K. S. (College of Oriental Medicine, Kyunghee University) ;
  • Kim, J. U. (Department of Obstetrics and Gynecology, Gumi CHA General Hospital, Pochon CHA University) ;
  • Lim, J. M. (Infertility Medical Center of Cha General Hospital, Pochon CHA University) ;
  • Song, B. K. (College of Oriental Medicine, Kyunghee University) ;
  • Chang, J. B. (College of Oriental Medicine, Kyunghee University) ;
  • Ko, J. J. (Infertility Medical Center of Cha General Hospital, Pochon CHA University) ;
  • Yoon, T. K. (Infertility Medical Center of Cha General Hospital, Pochon CHA University) ;
  • Park, Chan (Infertility Medical Center of Cha General Hospital, Pochon CHA University) ;
  • Cha, K. Y. (Infertility Medical Center of Cha General Hospital, Pochon CHA University)
  • 정형민 (포천중문의과대학교 차병원 여성의학연구소) ;
  • 이경섭 (경희대학교 한의과대학) ;
  • 김종욱 (포천중문의과대학 구미차병원 산부인과) ;
  • 임정묵 (포천중문의과대학교 차병원 여성의학연구소) ;
  • 송병기 (경희대학교 한의과대학) ;
  • 장준복 (경희대학교 한의과대학) ;
  • 고정재 (포천중문의과대학교 차병원 여성의학연구소) ;
  • 윤태기 (포천중문의과대학교 차병원 여성의학연구소) ;
  • 박찬 (포천중문의과대학교 차병원 여성의학연구소) ;
  • 차광렬 (포천중문의과대학교 차병원 여성의학연구소)
  • Published : 2000.04.01
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Abstract

This experiment was undertaken to investigate the effect of administration of Agyoju or Mokhyang on the maintenance of pregnancy, delivery and sex ratio in the mice in different gestation periods. Adult female mice were administered orally at three different periods, from ovulation to implantation (Exp.1), from post-implantation to organogenesis (Exp.2), and from fetal growth to parturition (Exp.3). In Experiment 1, number of fetus implanted and mean body weight were not significantly different. However, the delivery of male offspring was significantly increased in Agyoju and Mokhyang administrated groups than control group. In Experiment 2, the number of fetuses implanted, live offsprins and their body weight at delivery were significantly increased in the Agyoju administered group than Mokhyang and control groups. In Experiment 3, the number of live offspring and sex ratio were not different in both treatments and control group. However, mean body weight at delivery was significantly increased in both treatment groups than that of control group. These results suggest that 1) Agyoju and Mokhyang have beneficial effects in maintenance of pregnacy, and that 2) The action of unknown component(s) in Agyoju may be related to selection of male spermatozoa for fertilization in vivo, and that 3) the administration of Agyju of Mojhyang during mid-and late-pregnance periods were shown the increment of body weight of live offspring without decrease of litter size.

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