Cytotoxicity of Garlic and Onion Methanol Extract on Human Lung Cancer Cell Lines

인체 폐암세포주에 대한 마늘과 양파 메틴올추출물의 세포독성

  • 노숙령 (중앙대학교 식품영양학과) ;
  • 한지혜 (중앙대학교 식품영양학과)
  • Published : 2000.10.01

Abstract

This study was designed to investigate the cytotoxic effect of methanol extract of garlic, onion and those mixture on two kinds of human lung cancer cell lines (NCI-H522, NCI-H596) using MTT assay. MeOH extract of garlic, onion and those mixture showed cytotoxic effect on both NCI_H522 and NCI-H596. The growth of the cancer cells exposed to medium containing garlic, onion extracts and those mixture was inhibited dose-dependently. The growth of NCI-H522 was inhibited more in the garlic extract than in the onion extract, but that of HCI-H596 was inhibited highese in the onion extract. IC50 values of garlic extract on NCI-H522 and NCI-H596 were 0.84 mg/mL, 0.88 mg/mL and those of onion extract were 1.04 and 0.79, respectively. and the mixture of garlic and onion extracts also inhibited the growth of both NCI-H522 and NCI-H596 cells.

Keywords

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