Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지

Antimutagenic Effects of Persimmon Leaf Tea Extract (PLTE) in Mice Using Micronucleus Induction (MN) Test

마우스 소핵(Micronuclei, MN) 시험방법을 이용한 감잎차 추출물의 돌연변이 억제효과

  • 송현순 (한국화학연구소 안정성 연구센터) ;
  • 이현걸 (한국화학연구소 안정성 연구센터) ;
  • 강명희 (한남대학교 식품영양학과)
  • Published : 2000.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

The antimutagenic effects of persimmon leaf tea extract (PLTE) at concentration levels consumed by human were examined in mice using micronuleus induction with MMC(mitomycin C) or 4-NQO (4-nitroquinoline-1-oxide). When mice received oral gavage of 10 equivalent to PLTE 24 hr and 6 hr before, and 5 equivalent to PLTE 6 hr before and 3 hr after intraperitoneal injection of MMC, a significant decrease in the frequency of micronuclei were observed. The induction of micronuclei by 4-NQO was suppressed by oral dosage of PLTE at 5 equivalent to PLTE 6 hr before and 3 hr after, 10 equivalent to PLTE 3 hr before and 3 hr after intraperitoneal injection of MMC. Though the components of PLTE have not been analyzed so far, our present results suggest the existence of several bio-antimutagens and/or desmutagens in PLTE, beside catechin, well-known antimutagen.

Keywords

References

  1. J. Natl. Products v.50 Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity Kameda, K.;Takaku, T.;Okuda, H.;Kimura, Y.;Okuda, T.;Hatano, T.;Agata, I.;Arichi, S.
  2. Korean J. Food Sci. Technol. v.27 Changes of vitamin C and superoxide dismutase (SOD)-like activity of persimmon leaf tea by processing method and extraction condition Park, Y.J.;Kang, M.H.;Kim, J.I.;Park, O.J.;Lee, M.S.;Jang, H.D.
  3. Chem. Pharm. Bull. v.38 Prolongation of life span of stroke prone spontaneously hypertensive rats (SHRSP) ingesting persimmon tannin Uchida, S.;Ohta, H.;Niwa, M.;Mori, A.;Nonaka, G.;Nishioka, I.;Ozaki, M.
  4. J. Korean Soc. Food Nutr. v.25 Antimutagenic effects of persimmon leaf tea extracts in sister chromatid exchange (SCE) assay system Song, H.S.;Lee, H.K.;Jang, H.D.;Kim, J.I.;Park, O.J.;Lee, M.S.;Kang, M.H.
  5. Korean J. Food Sci. Technol. v.31 Effects of persimmon leaf tea extract, green tea extract and oolong tea extract on the frequencies of mutagen-induced sister chromatid exchange in mammalian cells Song, H.S.;Lee, H.K.;Roh, J.K.;Choi, E.H.;Kang, M.H.
  6. J. Korean Soc. Food Nutr. v.24 Antimutagenic effects of boiled water extract and tannin from persimmon leaves Moon, S.H.;Park, K.Y.
  7. J. Korean Soc. Food Nutr. v.25 Antimutagenic effect of persimmon leaves in vivo using sarcoma-180 cells Moon, S.H.;Kim, K.H.;Park, K.Y.
  8. J. Korean Soc. Food Sci. Nutr. v.22 Antimutagenic effects and compounds identified from hexane fraction of persimmon leaves Moon, S.H.;Kim, J.O.;Rhee, S.H.;Park, K.Y.;Kim, K.H.;Rhew, T.H.
  9. J. Korean Soc. Food Sci. Nutr. v.29 Effect of persimmon leaves (Diosphros kaki folium) extract on serum and liver lipid concentrations in hypercholesterolemic rats Park, J.-Y.;Park, E.-M.;Lee, M.-K.;Jang, J.-Y.;Kim, M.-J.;Cho, S.-Y.
  10. J. Korean Soc. Food Sci. Nutr. v.29 Effect of polyphenol compounds from persimmon leaves (Diospyros kaki folium)on antiallergy Park, M.-H.;Choi, C.;Son, G.-M.;An, B.-J.;Bae, M.-J.
  11. J. Korean Soc. Food Nutr. v.29 Effects of persimmon leaf tea extract (PLTE), green tea extract (GTE), oolong tea extract (OTE) on reversion and survival of selected Salmonella tester strains Song, H.S.;Lee, H.K.;Kang, M.H.
  12. In Mutagenecity testing : a practical approach Cytogenetic tests in mammals Alder, I.D.;Venitt, S.;Parry, J.M.(eds.)
  13. Mutation Res. v.31 The micronucleus test Schmid, W.
  14. Mutation Research v.244 In vivo anticlastogenic and antimutagenic effects of tannic acid in mice Sasaki, Y.F.;Matsumoto, K.;Imanishi, H.;Watanabe, M.;Ohta, T.;Shirasu, Y.;Tutikawa, K.
  15. Mutation Res. v.259 Tea tannin components modify the induction of sister chromatid exchanges and chromosome aberrations in mutagen treated cultured mammalian cells and mice Imanishi, H.;Sasaki, Y.F.;Ohta, T.;Watanabe, M.;Kato, T.;Shirasu, Y.
  16. Mutation Research v.286 The clastogen-suppressing effect of green tea, Po-lei tea and Rooibos tea in CHO cells and mice Sasaki, Y.F.;Yamada, H.Shimoi, K.Kator, K.;Kimae, N.
  17. Korean J. Food Sci. Technol. v.26 Changes of chemical components in persimmon leaves during growth for processing persimmon leaves tea Chung, S.H.;Moon, K.D.;Kim, J.K.;Seong, J.H.;Sohn, T.H.
  18. Mutation Res. v.149 Bioantimutagenic effects of tannic acid on UV and chemically induced mutagenesis in Escherichia coli B/r. Shimoi, K.;Nakamura, Y.;Tomita, I.;Kada, T.
  19. In Environmental Mutagenesis, Carcinogenesis and Plant Biology Environmental desmutagens and antimutagens Kada, T.;Inoue, T.;Namiki, M.;Klekowski, D.(ed.)
  20. Mutation Res. v.213 Suppressing effect of tannic acid on the frequencies of mutagen-induced sister-chromatid exchanges in mammalian cells Sasaki, Y.F.;Imanish, H.;Ohta, T.;Watanabe, M.;Matsumoto, K.;Shirasu, Y.
  21. Agric. Biol. Chem. v.52 Suppressing effect of tannic acid on UV and chemically induced chromosome aberrations in cultured mammalian cells Sasaki, Y.F.;Imanishi, H.;Ohta, T.;Watanabe, M.;Matsumoto, K.;Shirasu, Y.
  22. J. Korean Sco. Food Nutr. v.24 Dismutagenicity of tea extracts from green tea, oolong tea and black tea Yoo, S.G.;Kim, I.S.;Ahn, C.W.;Kim, S.B.;Park, Y.H.
  23. Mutation Res. v.150 Detection and chemical identification of natural bioanti-mutagens. A case of green tea factor Kada, T.K.;Kaneko, S.;Matsuzaki, T.M.;Hara, Y.
  24. J. Agr. Food Chem. v.43 Antioxidant activity of various tea extracts in relation to their antimutagenicity Yen, G.C.;Chen, H.Y.
  25. Mutation Res. v.222 Chromosome aberrations induced by aflatoxin B1 in rat bone marrow cells in vivo and their supperssion by green tea Ito, Y.;Ohnishi, S.;Fujie, K.
  26. Mutagenesis v.11 A comparison of the antimutagenic potential of green, black and decaffeinated teas : contribution of flavanols to the antimutagenic effect Bu-Abbas, A.;Nunez, X.;Clifford, M.N.;Walker, R.;Ioannides, C.
  27. Mutation Res. v.223 Antimutagenic activity of green tea polyphenols Wang, Z.Y.;Cheng, S.J.;Zhou, Z.C.;Athar, M.;Khan, W.A.;Bickers, D.R.;Mukhtar, H.
  28. J. Korean Soc. Food Sci. Nutr. v.29 Effect of polyphenol compounds from persimmon leaves (Diosphros kaki folium) on antiallergy Park, M.-H.;Choi, C.;Son, G.-M.;An, B.-J.;Bae, M.-J.