Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Antimutagenic and DNA Topoisomerase I Inhibition Effects of Sarcodon aspratus Extracts

향버섯(Sarcodon aspratus)추출물의 항돌연변이성 및 DNA Topoisomerase I 저해 효과

  • 배준태 (영남대학교 식품영양학과) ;
  • 이갑랑 (영남대학교 식품영양학과)
  • Published : 2000.10.01
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Abstract

This study was carried out to investigate the effects on the mutagenicity and activity of DNA topoisomerase I of Sarcodon aspratus. Using an Ames mutagenicity test, which has been used to assess both mutagenic and antimutagenic effects of various molecules, it was observed that the methanol extracted fraction and other fractions (prepared in water or ethylacetate) of Sarcodon aspratus showed a significant antimutagenic activity against a mutagenecity induced by both a direct mutagenic agent such as MNNG and an indirect mutagenic agents such as B(a)P and AFB$_1$in Salmonella typhimurium TA98, TA100. Also, the extract and fractions of Sarcodon aspratus were found to have an inhibitory activity on the relaxation process of DNA topoisomerase I.

Keywords

References

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