Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지

Toxic Effects of the Megadose Garlic Juice in the Rats

마늘즙을 다량 투여한 흰쥐에서 체중과 장기 및 혈액 성분의 변화 고찰

  • 서화중 (조선대학교 식품영양학과)
  • Published : 2000.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

흰쥐에 사료 섭취량의 3%(G3군)와 5% (G3군)인 과량의 생마늘(즙)을 1개월간 경구 투여하여 체중 증가율과 사료 섭취량은 큰 영향을 받지 않았다. 흰쥐 외관과 활동도는 별다른 변화가 없었으나 해부 검사에서 G3군 흰쥐일부와 G3군 대부분의 흰쥐의 위벽점막에 홍반(erythema)를 관찰할 수 있었다. 간조직의 현미경 검사에서 G3군의 3마리 흰쥐에서 주로 간 실질세포으 퇘행성 변화와 염증세포의 침윤 등을 관찰했고 G5군의 7마리 흰쥐는 주로 간실질세포의 염증성세포 침윤과 충혈 및 경미한 간세포 괴사를 보였다. GOT와 GPTalc alkaline phosphatase 활성과 BUN수준에서 G3군과 G5군은 dose dependent fashion으로 모두 대조군보다 유의성있게 증가하였다. Total cholesteroltnwns과 hemoglobin함량은 G3군과 G5군에서 유의적인 변화를 보이지 않았다. 이상의 본 실험 결과를 보면 흰쥐에 과량의 마늘을 장기간 투여할 때 명백하게 독성이 나타남을 관찰할 수 있었다.

Keywords

References

  1. Jeuungbo Dongeubogam Huh, J.
  2. Dohae bonchogangmok Lee, S. J.
  3. Applied Microbiology v.17 Death of Salmonella typhimurium and Escherichia coli in the presence of freshly reconstituted dehydrated garlic and onion Michael, G. J.;Reese, H. V.
  4. J. Gesellschaft Deutsher Chemikal v.31 The organo sulfur chemistry of genus Alliium-implication for the organic chemistry of sulfur Block, E.
  5. J. R. Coll. v.28 Garlic as a lipid lowering agent, a meta analysis Silagy, C.;Neil, A.
  6. Arzneimittelforschung v.40 Treatment of hyperlipidaemia with garlic powder tablets. Evidence from the German Association of General Practitioners' multicentric placebo-centrolled double-blind study Mader, F. H.
  7. Lipids v.29 Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis Yu, Y. Y.;Shaw, M. Y.
  8. FEBS Letters v.261 Allicin, a naturally occurring antibiotic form garlic, specically inhibits acetyl-CoA synthetase Focke, M.;Feld, A.;Lichtenthaler, K.
  9. Indian J. Exp. Biol. v.30 Antidiabetic effects of S-allylcysteine sulphoxide isolated from garlic Allium sativum Linn Sheela, C. G.;Augusti, K. T.
  10. Arzneimittelforschung v.41 Inhibition of cholesterol biosynthesis by a water-soluble garlic extract in primary cultures of rat hepatocytes Gebhardt, R.
  11. Prostaglandins. Leukot. Essent. Fatty Acids v.53 Consumption of a garlic clove a day could be beneficial in preventing thrombosis Ali, M.;Thomson, M.
  12. Arzneimittelforschung v.43 Effects of a dried garlic preparation on fibrinolysis and platelet aggregation in healthy subject Legnani, C.;Frascaro, M.;Guazzaloca, G.;Ludovici, S.;Cesarano, G.;Coccheri, S.
  13. J. Postgrad. Med. v.37 Effect of ingestion of raw garlic on serum cholesterol level, clotting time and fibrinolytic activity in normal subjects Gadkari, J. V.;Joshi, V. D.
  14. v.132 Garlic-always good for the health?[letter] Canduela, V.;Mongil, I.;Carrascosa, M.;Docio, S.;Cagigas, P.
  15. Int. J. Cardiol. v.38 Garlic-the other side of the coin[letter] Gupa, M. K.;Mittal, S. R.;Mathur, A. K.;Bhan, A. K.
  16. J. Ethnopharmacol. v.29 Effect of Allium sativum on epididymal spermatozoa, estradioltreated mice and general toxicity al-Bekairi, A. M.;Shah, A. H.;Qureshi, S.
  17. v.26 Spontaneous spinal epidural hematoma with associated platelet dysfunction from excessive garlic ingestion : a case report[see comments] Rose, K. D.;Croissant, P. D.;Parliament, C. F.;Levin, M. B.
  18. Indian J. Exp. Biol. v.27 Toxic effects of garlic extract and garlic oil in rats Joseph, P. K.;Rao, K. R.;Sundaresh, C. S.
  19. Arzneimittelforschung v.42 Comparision of the efficacy and tolerance of a garlic preparation vs. bezafibrate Holzgartner, H.;Schmidt, U.;Kuhn, U.
  20. Toxicol. Lett. v.85 Histopathological effects of garlic on liver and lung of rats Alnaqeeb, M. A.;Thomson, M.;Bordia, T.;Ali, M.
  21. Food Chem. Toxicol. v.35 Cytotoxicity and genotoxicity of diallylsulfide and diallyl disulfide towards Chinese hamster ovary cells Musk, S. R.;Clapham, P.;Johnson, I. T.
  22. Food Chem. Toxicol. v.34 Effect of the active principle of garlic-diallyl-sulfide-on cell viability, detoxification capability and the antioxidation system of primary rat hepatocytes Sheen, L. Y.;Lii, C. K.;Sheu, S. F.;Meng, R. H.;Tsai, S. J.
  23. Am. J. Chinese Med. v.27 Effect of garlic active principle, diallyl disulfide, on cell viability, lipid peroxidation, glutathione concentration and its related enzyme activities in primary rat hepatocytes Sheen, L. Y.;Sheu, S. F.;Tsai, S. J.;Meng, R. H.;Lii, C. K.
  24. Indian J. Exp. Biol. v.35 Biochemical studies on combined effects of garlic(Allium sativum Linn) and ginger(Zingiber officinale Rosc) in albino rats Ahmed, R. S.;Sharma, S. B.
  25. Planta Medica v.52 Antihepatotoxic action of Allium sativum bulbs Hikino, H.;Tohkin, M.;Bukiso, Y.;Namiki, T.;Nishimura, S.;Takeyama, K.
  26. The laboratory rats, II Baker, H. J.;Lindsey, J. R.;Weisbroth, S. H.
  27. Hangeul SPSS
  28. J. Med. Korean v.10 Comparative study of the allicin and arsenite on albino rats with special regard to the effects on body weight, hemoglobin and hepatic histology Lee, Y. S.
  29. Am. J. Med. v.94 Can garlic reduce levels of serum lipids? A controlled clinical study Jain, A. K.;Vargas, R.;Gotzkowsky, S.;McMahon, F. G.
  30. Arch. Toxicol. v.63 Toxicity study in rats of a tellurium based immunomodulating drud, AS-101 : a potential drug for AIDS and cancer patients Nyska, A.;Waner, T.;Pirak, k.;Sledni, B.
  31. Korean J. N. v.1 Histopathological and histochemical studies on the effect of garlic and garlic oil to the rats Ro, I. H.;Lee, S. Y.
  32. The Assocition of Korean Clinical Pathology : The clinical pathology
  33. British J. Rheumatology v.33 Even garlic[letter] Sweetman, B. J.
  34. J. Biochem. Mol. Toxicol. v.13 Decrease of hepatic catalase level by treatment with diallyl sulfied and garlic homogenates in rats and mice Chen, L.;Hong, J. Y.;So, E.;Hussin, A. H.;Cheng, W. F.;Yang, C. S.
  35. J. Korean Soc. Food Sci. Nutr. v.28 Effects of garlic on the blood lipids and other serum components in rats Sheo, H. J.
  36. Med. Hypotheses v.44 How does garlic exert its hypocholester-olaemic action? The tellurium hypothesis Larner, A. J.
  37. Plastic Reconstr. Surg. v.96 Garlic and postoperative bleeding[letter : comment] Petry, J. J.
  38. Plastic Reconstr. Surg. v.95 Garlic as a possible risk for postoperative bleeding[letter] Burnham, B. E.
  39. Schweizerische Rundschau fur Medizin Praxis v.84 Garlic-a secret miracle of God? Biedermann, B.