Journal of Nutrition and Health

  • 제33권2호
  • /
  • Pages.134-140
  • /
  • 2000
  • /
  • 2288-3886(pISSN)
  • /
  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지

N-3rP 지방산이 나이가 다른 흰주의 신장 기능에 미치는 영향

Effects of N-3 Fatty Acids on Renal Function in Rats of Different Ages

  • 김화영 (이화여자대학교 가정과학대학 식품영양학과)
  • 발행 : 2000.03.01
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초록

This study was performed to investigate the effects of n-3 fatty acids on renal function in male Sprague-Dawley rats of different ages 5-, 15- and 19-months old. The rats were fed a 20%(w/w) lipid diet containing 10% fish oil, compared with control animals fed a 20% lipid diet without fish oil for 4 weeks. The results were as follows: kidney weights were significantly higher in fish oil-fed rats compared to control rats. Plasma levels of total lipid, total cholesterol, and triglyceride markedly increased, with aging and LDL-cholesterol showing a significantly lower level in fish oil-fed rats than control rats. The urinary protein and glomerular filtration rate (GFR) increased with aging. GFR was higher in fish oil-fed rats. However, urinary protein was the same in the two groups. Renal medulla thromboxane B$_2$(TXB$_2$)tended to be lower in fish oil-fed 19-month-old rats. Urinary TXB$_2$and PGE$_2$were found to be higher proteinuria. Light microscopic examination showed interstitial inflammation, tubular atrophy, interstitial fibrosis and glomerular mesangium increase. Although glomerular sclerosis increased with aging, fish oil in the diet had no effect on histological changes. In conclusion, plasma lipid, urinary protein excretion and renal histological change showed a significant increase with aging. The reduction of TXB$_2$in the medulla and increase of GFR caused by fish oil indicated n-3 fatty acid could affect renal function in line with the hypolipidemic effect.

키워드

참고문헌

  1. Virchowa Arch(Cell Pathol) v.51 Glomerular sclerotic lesions in the rat Grond J;Van Goor H;Erkelens SW;Elema JD
  2. Am J Soc Nephrol v.7 no.8 Ovariectomy decrease plasma triglyceride levels and both prevents and alleviates glomerural disease in uninephrectomized female analbuminemic rats Joles JA;Van Goor H;Van Tol A;Weening JJ;Koomans HA
  3. Am J Physiol v.251 Platelet-activating factor and the kidney Schonorff D;Neuwrith R
  4. The Effect of tuna and perilla oil on lipid metabolism and production of thrombus of rat Chung HL
  5. J Nutr v.107 Ad Hoc committe on standard for nutritional studies Report of the American Institute of Nutrition
  6. Korean J Nutr v.25 The effects of age and dietary protein level on Ca metabolism in rats Lee JA;Jang YA;Kim EY
  7. Korean J Nutr v.29 no.10 Effect of dietary protein level on renal function: Lipid and eicosanoids metabolism in uninephrectomized aging model rats KimWY;Lee HS
  8. Am J Clin Pathol v.53 A colorimetric method for determination of total serum lipids based on the sulfophospho-vanillin reaction Frings GS;Dunn RT
  9. Total and free cholesterol. In standard method of clinical chemistry Zak B
  10. Clin Chem v.21 A manual colorimetrick assay of trigyceriden serum Biggs Hg;Erickson JM;Moorehead WR
  11. Clin Chem v.18 Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge Frieldward WT;Levy RI;Fredrick DS
  12. Hawk's physiological chemistry 4th edition Oser BL
  13. Clinical medicine Lee KN;Kim JK
  14. J Biol Chem v.193 Protein measurement with the Folin phenol reagent Lowry OH;Resebrouh NJ;Randal RJ
  15. Am J Clin Nutr v.66(suppl) Are fish oils beneficial in the prevention and treatment on coronary artery disease? Connor SL;Connor WE
  16. J Nutr v.128 Dietary fatty acids and the regulation of plasma low density lipoprotein cholesterol concentrations Dietschy JM
  17. Am J Nutr v.49 Dietary modulation of the progression of nephropathy in aging rats: an evaluation of the importance of protein Masoro EJ;Iwasaki K;Gleiser CA;Mcmahan CA;Yu BP
  18. Hepatology v.22 no.1 Renal effects of dietary supplementation with fish oil in cyclosporine-trated liver transplant recipients Badalamenti S;Saleno F;Ponticelli C(et al.)
  19. Korean J Nutr v.31 no.3 Effect of different types of dietary fat on renal functions in aged rats Kim WY;Lee SJ;Jeong HJ
  20. Am J Clin Nutr v.53 Lack of dose response by dietary n-3 fatty acids at a constant ratio of n-3 to n-6 fatty acids in suppressing eicosanoid biosynthesis from arachidonic acid Boudreau MD;Chanmugam PS;Hart SB;Lee SH;Hwang DH
  21. J Immunol v.134 no.3 A fish oil diet rich in eicosapentaenoic acid reduces cyclooxygenase metabolites, and suppresses lupus in MRL-1pr mice Kelley VE
  22. Transplantation v.45 no.1 Selective enhancement of thromboxane in macrophages and kidneys in cyclosporine-induced nephrotoxicity Rogers TS;Elzinga;Bennett Wm;Kelley VE
  23. J Pharmacol Exp Ther v.234 Arachidonic acid metabolism and urinary excretion of prostaglandins and thromboxane in rats with experimental diabetes mellitus Quelley J;McGiff JC
  24. European J Phamacol v.316 no.1 Effect of DP-1904, a thromboxane A₂synthase inhibitor, on passive Heymann nephritis in rats Nagao T;Nagamatsu T;Suzuki Y
  25. Seminars in Nephrol v.15 The effect of nonsteroidal anti-inflammatory drugs on renal function: experimental studies in animals Zambraski EJ
  26. J Am Soc Nephrol v.5 no.8 Down-regulation of the intrarenal renin-angiotensin system in the aging rat Jung FF;Kennefick TM;Anderson S