Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

The Effect of BuOH Fraction of Polygonatum odoratum with Selenium on Blood Glucose Level and Lipid Peroxidation in Streptozotocin Induced Diabetic Rats

둥굴레 분획물과 Selenium이 Streptozotocin 유발 당뇨 흰쥐의 혈당수준과 지질과산화에 미치는 영향

  • 임숙자 (덕성여자대학교 자연과학대학 식품영양학과)
  • Published : 2000.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study was to investigate the effect of butanol(BuOH) fraction of Polygonatum odoratum with selenium tr-eatment on blood glucose levels and lipid peroxidations in streptozotocin(STZ) induced diabetric rats. Male Sprague-Dawly rats weighing(180-200g) were divided into five groups : normal STZ-control and three expreimental groups(P, odoratum group P, odo-Se group and Se group) Diabetes mellitus was induced by injection STZ in the tail vein at the dose of 45mg/kg B.W The BuOH fraction of Polygonatum odoratum(500mg/kg. B,W) given orally administered for 14 days. The Se treated group were fed a AIN-76 recommendation diet mixed with Na2Seo3(2mg/kg diet). Diabetic rats showed the lower weight gain compared to the normal rats. the plasma glucose levels of the P. odo-Se group were significantly lower than the other experimental groups. The plasma cholesterol levels were higher in STZ-control and Se groups compared toP.odoratum and P. odo-Se groups and HDL-cholesterol levels were increased in the diabetic experimental groups fed on BuOH fraction of P. odoratum with Se supplementation. The liver and muscle glycogen levels were not significantly differ among all groups. The plasma free fatty acid levels were lower in diabetic experimental groups fed on BuOh fraction of P. odoratum or Se sup-plementation than STZ-control and Se groups. Diabetics rats showed the higher levels of triglyceride in plasma andlower levels in liver compared with the normal group. Supplementation with Se decreased significantly the liver triglyceride level. The MDA levels in liver and kidney were significantly reduced in all the experimental groups. In conclusion administration of BuOH fraction of Polygonatuum odoratum with selenium supplementation reduced blood glucose levels and peroxdative tissue damage in STZ induced diabetic rats showing the possibility of preventiave and therapeutic use of the wild edible plant to the diabetes mellitus.

Keywords

References

  1. Todays therapy for diabetes Lee JC
  2. Diabetes Mellitus (12th ed.) Narle A;Krall LP;Bradley RF;Christlieb AR;Soell JS;Joslin's'
  3. Diabetes Care v.13 Screening for diabetes
  4. JAMA v.241 Diabetes and cardiovascular disease Kannel WB;McGee DL
  5. Agric Biol Chem v.43 Isolation of 2 Amino-9H-pyrido-2, 3-b indole and 2-amino-3-methyl-9HO pyrido 2, 3-d indole as mutagens from pyrolysis product of tryptophan Yoshida D;Matsumoto T
  6. Mutation Res v.53 Animutagenic action of vegetable factor on the mutagenic principle of typtophan pyrolysate KadaT;Morita K;Inoue T
  7. Mutation Res v.77 Antimutagenic activities of common vegetable and their chlorophyll content Lai CN;Butler MN;Matney TS
  8. Nutrition and diabetes The role of the diet in improving glycemic control Mendez CM;Stoecker BJ;Javanovic L;Peterson CM(eds.)
  9. Diabetes Care v.12 Traditional plant medicines as treatments for diabetes Bailey CJ;Day C
  10. Planta Medica v.50 Effects of Euphobia prostrata and Fumaria plaviflora in normoglecaemic and alloxan-treated hyperglycemic rabbits Akhtar MS;Kham QM;Khaliq T
  11. Kor J Pharmacogn v.21 A Preliminanary study on hypocholesterolemic and hypoglycemic activities of some medicinal plants Choi JS;Chung HY;Han SY
  12. Pharmacogn Sci v.7 Studies on the physiochemical activities of Commelinea Herba extract on the normal and the strptozotocin-induced hyperglycemic rats, Thesis collection Kim TH;Yang KS;Whang SH
  13. Planta Medica v.52 Tormentic acid, a new hypoglycemic agent from Poterium ancistoioes Villa A;Paya H;Hortiguela MD;Cortes D
  14. Lipids v.26 Vitamin E and the susceptibility of erythrocytes and reconstituted liposomes to oxidative stress in aged diabetic Urano S;Midori HH;Tochihi N;Matsuo M;Shiraki M;Ito H
  15. Metabolism v.40 Vitamin C and vitamin E status in the spontaneously diabetic BB rat before the onset of diabetes Behrens WA'Madere R
  16. Diabetes v.35 Triglyceride-lowering effects of dietary vitamin E in streptozotocin-induced diabetic rats. Increased lipoprotein lipase activity in livers of diabetic rats fed high dietary vitamin E Prichard KA;Patel ST;Karper CW;Newman HAI;Panganamala RV
  17. Sci v.201 The biology of oxygen radicals. the syperoxide radical as an agent of oxygen toxicity: superoxide dismutase provides an important defense Frielovich I
  18. Effects of dietary vitamin E on the antioxidative defense mechanism and metallothionein synthesis in streptozotocin-induced diabetic rats Choi WK
  19. J Nutr v.119 Recent developments in trace element metabolism and function: Newer roles of selenium in nutrition Burk RF
  20. Nutr Rev v.56 The influence of antioxidant nutrients in viral infection Beck MA
  21. Am J Clin Nutr v.66 Vitamins and minerals: Efficacy and safety Hathcock JN
  22. Iillustrate flora of Korea Lee TB
  23. Korea J Nutr v.28 The effects of Korean wild vegetables on blood glucose levels and liver-muscle metabolism of streptozotocin-induced diabetic rats Lim SJ;Kim SY;Lee JW
  24. Kor J Nutr v.28 Hypoglycemic effect of Polygonatum Odoratum var. Puriflorum Ohwi extract in streptozotocin-induced diabetic rats Lim SJ;Kim GJ
  25. Diabetes v.30 Diabetes induced with multiple subdiabetogenic doses of streptozotocin Gold G;Manning M;Heldt A;Nowlain R;Pettit JR;Grodsky GM
  26. J Clin Invest v.48 Diabetogenic action of streptozotocin: Relationship of dose to metabolic response Junod A;Lambert AE;Stauffacner W;Renold AE
  27. J Lab Invest v.12 On the enzymatic determination of blood glucose Rabbo E;Terkildsen TC
  28. J Clin Endocrinol Metab v.33 Use of polythylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays Desbuquois B;Aurbach GB
  29. Methods in Enzymology 3 Chemical procedures for analysis of polysaccharides Hassid WZ;Abraham X
  30. Clin Chem v.19 Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum Richmond W
  31. J Clin Chem v.20 Enzymatic determination of total serum cholesterol Allain CC;Poon LS;Chan CSG;Richmond W;Paul C Fu
  32. J Clin Chem v.21 Serum triglyceride determined colormetry with and enzyme that produces hydrogen peroxide Giegel JL;Ham SB;Clema W
  33. 他. 臨床檢査提要 改訂 弟29版 金井 泉
  34. Clin Chem v.24 Cholesterol in high density lipoprotein: Use of $Mg^{2+}$ /dextran sulfate in its measurement Finely PR;Schifman RB;Willams RJ;Luchti DA
  35. Anal Biochem v.86 Determination of malondialdehyde precursor in tissue by thiobarbituric acid test Uchiyma M;Mihara M
  36. Am J Clin Pathol v.28 A colorimetric method the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases Reitman S;Frankel S
  37. PC-STAT Rao M;Blane K;Zonnenberg M
  38. Diabetes v.35 STZ diabetes alters immunoreactive β-endorphin levels and pain perception after 8wk in female rats Forman S;Estilow ML;Vailenko P
  39. J Nutr v.123 Dietary sorbose prevents and improves hyperglycemia in genetically diabetic mice Furuse M;Kimura C;Mabayo RT;Takahashi H;Okumura J
  40. Endocrinolgy v.119 Phenylethanolamin N-methyltransferase in the basis of STZ diabetic rats Fisher KJ;Stewart JK
  41. Diabetes v.43 Skeletal muscle vascular transport capacity in diabetic rats Sexton WL
  42. J Kor Nutr v.27 Effects of buckwheat on organ weight, glucose and lipid metabolism in streptozotocin-induced diabetic rats Lee JS;Son HS;Maeng YS;Chang YK;Ju JS
  43. J Kor Soc Food Nutr v.21 Pretreatment with nicotinamide to prevent the pancreatic enzymes change by streptozotocin in rat Shon KH;Kim SH;Ghoi JW
  44. Ann Rev Med v.36 The molecular mechanism of insulin action Kahn CR
  45. Kor J Nutr v.29 Effects of vitamin E and selenium in the antioxidative defense system in streptozotocin-induced diabetic rats Lee SY;Choe WK;Cha BK;Yang JA;Kim KY
  46. Diabetes v.35 Identification of glucokinase as an a alloxan-sensitive glucose sensor of the pancreatic β-cells Meglasson MD;Burch PT;Berner DK;Najafi H;Matschinsky FM
  47. Diabetes v.39 Cholesterol metabolism in alloxan-induced diabetic rabbits O'Meara NMG;Devery RAM;Owens D;Collins PB;Johnson AHTomkin GH
  48. J Kor Soc Food Nutr v.20 Effects of nicotinamide on the serum lipid composition in streptozotocin-induced diabetic rats Choi JW;Sohn KH;Kim SH
  49. Kor J Nutr v.30 Effects of mushroom protein-bound polysaccharides on blood glucose levels and energy metabolism in streptozotocin-induced diabetic rats Kim MW;Park MH;Kim KH
  50. Metabolism v.22 Plasma triglyceride transport kinetics in diabetes mellitus Nikkila EA;Kekki M
  51. Diabetes v.39 Defective free fatty acid and oxidative glucose metabolism in NIDDM during hypoglycemia Caprio S;Amiel S;Tamborlane WV;Gelfand RA;Sherwin RS
  52. J Kor Diabetes Assoc v.10 The relationship between the postprandial HDL subfraction and triglyceride in diabetes mellitus Choi SK;Yoon KH;Yang IM;Kim JW;Kim YS;Kim KW;Choi YK;Park WK;Kim SW
  53. Eur J Clin Invest v.26 Multiple abnormalities in the transfer of phospholipids from VDL and LDL to HDL in non-insulin-dependent diabetes Elchebly M;Pulcini T;Porokhov B;Berthenene F;Ponsin G
  54. J Nutr v.118 Effects of various dietary levels of selenium as selenite or selenomethionine on tissue selenium levels and glutathione peroxidase activity in rats Whanger PD;Butler JA
  55. Diabetes Res and Clin Practice v.30 The vitamin E derivative U-83836-E in the low dose streptozotocin-treated mouse: Effects on diabetes development Paccio G;Baccari GC;Frascatore S;Sellitti S;Pisanti FA
  56. Kor J Nutr v.30 Effect of Artemisia princeps var orientalis and Circium japonicum var ussuriense on liver function, body lipid, and bile acid of hyperlipidemic rat Lim SS;Kim MH;Lee JH