Effect of Propolis on Healing of Full-thickness Skin Wound in Rabbits

Propolis가 토끼의 전층 피부 창상치유에 미치는 영향

  • 정성일 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 강성수 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 조성구 (충북대학교 농과대학) ;
  • 정석화 (충북대학교 수의과대학 및 동물의학연구소)
  • Published : 2000.06.01

Abstract

The effects of vaselin, silver sulfadiazine and propolis on healing of full-thickness skin defects were evaluated in rabbits. Two wounds measuring 2{times}2cm$ were created bilaterally (4 wounds/rabbit) on the dorsolateral aspect of the trunk of 17 Ne Zealand white. Wound treatments were evenly distributed 4 sites, using a Latin square design. Treatments evaluated were: vaselin(group A), silver sulfadiazine(group B), 5% propolis (group C) and 10% propolis(group D). On days 3, 7 and 14, mean percentage of wound in group A, B, and C. On days 21 and 28, mean percentage of wound contraction in group D were significantly higher than those of groups B and C, but were not higher than that of group A. Microscopically fibersis and epithelialization were noticed on days 14 and 28 after wounding in all group. Rates of fibrosis of collagen fiber and epithelialization of groups C and D were exceeded those of groups A and B. All wounds in all group achieved 100% healing during the 28-day study period. Results indicate that use of propolis as would ointment on full-thickness skin wounds in rabbits increase rate of healing.

Keywords

References

  1. Rom J Virol v.46 Natural propolis extract Nivcrisol in the treatment of acute and chronic rhinopharyngitis in children Crisan I;Zaharia CN;Popovici F;Jucu V;Belu O;Dascalu C;Mutiu A;Petrescu A
  2. J Invest Dermatol v.74 'Inert' vehicles do affect wound healing Eaglestein wH;Mertz PM
  3. Effect of topical medicaments on the rate of repair superficial wounds Eaglestein WH;Mertz, PM
  4. Clin Dermatol v.2 Effects of topically applied agents on healing wounds eaglestein WH;Mertz PM;Alvarez OM
  5. Ann Surg v.167 Effects of cortisone and vitamin A on wound healing Erlich P;Hunt YK
  6. Pharmacol Res Commun v.18 Free amino acids in bee hive product (propolis) as identified and quantified by gas-liquid chromatography Gabrys J;Konecki J;Krol W;Scheller S;Shani J
  7. Arch Dermatol v.115 Wound healing: The effects of topical antimicrobial agents Geronemus RG;Merz pM;Eaglestein WH
  8. Honeybee Science v.15 Effects of propolis on dental caries in rats Ikeno K;Miyazawa T
  9. Vet Clin Nor Am v.20 Wound healing in skin.In:Plastic and reconstructive surgery Johnsenm DE
  10. Am Bee v.107 Antimicrobial activity of propolis Lindenfelser LA
  11. J Nihon Univ Sch Dent v.32 Application of propolis to dental sockets and skin wounds Magro-Filho O;de Carvalho AC
  12. Bioorh Khim v.21 Lipophilic derivatives of caffeic acid as liplxygenase ingibitors with antioxidant properties Mirzoeva OK;Sudina GF;pushkareva MA;Korshunova GA;Sumbatian NV;Varfolomeev SD
  13. Proc Natl Acad Sci v.93 Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B Natarajan K;Singh S;Burke Jr TR;Grunberger D;Aggarwal BB
  14. Cornea v.18 The effects of acetylcholine and propolis extract on corneal epithelial wound healing in rats Ozturk F;Kurt E;Inan UU;Emiroglu L;Ilker SS
  15. pharmazie v.34 On the local anaesthetic action of propolis and some of its constituents Paintz M;Metzner J
  16. Wound Hialing,In:Textbook of small animal surgery Prost CW;Bright RM
  17. Am J Vet Res v.56 Effects of three occlusive dressing materials healing of full-thickness skin wounds in dogs Ramsey DT;pope ER;Wager-Man C;Berg JN;Saim SF
  18. Pharmazie v.41 Inhibition of bacterial DNA-dependent RNA polymerases and restriction endocuclease by UV-absorbing components from propolis Simuth J;Trnovsky J;Jelokova J
  19. Arzneimittelforschung v.27 Biological properties and clinical application of propolis.Ⅱ.Studies on the antiprotozoan activity of ethanol extract of propolis Starzyk J;Scheller S;Szflarski J;Moskawa M;stojko A
  20. Arzneumittelforschung v.28 Biological properties and clinical application of propolis.Ⅷ. Experimental observation on the influence of ethanol extract of propolis (EEP) on the regeneration of bone tissue Starzyk J;Scheller S;Szwarnowiecka I;Tustanowski J;Ostach H;Obuszko Z
  21. wound dressing materials and topical medications In, Small animal wound management Swaim SF;Henderson RA
  22. Ann Rev Plant Physiol v.28 Secondary compounds as protective agents Swain T
  23. Br J Dermatol v.92 An explanation for the "placebo" effect of bland ointment bases Tree S;Marks R
  24. Vestn Khir v.134 Use of propolis in the treatment of lacal suppurative infection Tsarev NI;Petrik EV;Aleksandrova VJ
  25. Arzeimittelforschung v.46 Interactions of different extracts of propolis with leukocytes and leukocytic enzymes Volpert R;Elstner EF
  26. J Dermatol Surg Oncol v.15 The role of topical agents in the healing of full-thickness wounds Watcher MA;Wheeland RG
  27. 한국임상수의학회지 v.10 가토 창상치유에 대한 항균연고제의 효과 권오경
  28. 항국양봉학회지 v.9 천연항생물질 propolis의 특성과 효용에 대한 고찰 박형기
  29. 한국임상수의학회지 v.9 Chlorhexidine gluconate 및 povidone iodine이 가토의 창상치유에 미치는 효과 임성준;권오경;장광호
  30. 한축지 v.38 水抽出 propolis (WEp)에 의한 육제품 보존에 관한 연구 한승관;박형기