Journal of Ginseng Research
- 제24권4호
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- Pages.168-175
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- 2000
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- 1226-8453(pISSN)
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- 2093-4947(eISSN)
Mechanism of $Ca^{2+}$ -activated $Cl^-$ Channel Activation by Ginsenosides in Xenopus Oocytes
- Park, Seok (Department of Physiology, College of Veterinary Medicine, Chonnam National University) ;
- Jung, Se-Yeon (Department of Physiology, College of Veterinary Medicine, Chonnam National University) ;
- Park, Seong-Hwan (Department of Life Science, Kwangju Institute of Science and Technology) ;
- Ko, Sung-Ryong (Department of Physiology, College of Veterinary Medicine, Chonnam National University) ;
- Hyewon Rhim (Department of Physiology, College of Veterinary Medicine, Chonnam National University) ;
- Park, Chul-Seung (Department of Life Science, Kwangju Institute of Science and Technology) ;
- Nah, Seung-Yeol (Korea Ginseng & Tobacco Tesearch Iinstitute)
- 발행 : 2000.12.01
초록
Xenopus oocytes를 이용하여 인삼의 유효 성분으로 알려진 Ginseng total saponin(GTS)의 신호 전달 기작을 two electrode voltage clamp 방법을 이용하여 연구하였다. GTS는 세포 바깥에 처리했을 때 -2OmV보다 더 positive한 voltage에서 커다란 outward current를 유도하였다. 그러나, 세포 안쪽에 GTS를 injection할 경우 아무런 효과가 없는 것으로 나타났다. GTS처리에 의한 outward current유발 효과는 GTS 투여 용량에 의존적인 것으로 나타났다(EC
Relatively little is known about the signaling mechanism of ginseng saponins (ginsenosides), active ingredients of ginseng, in non-neuronal cells. Here, we describe that ginsenosides utilize a common pathway of receptor-mediated signaling pathway in Xenopus oocytes: increase in intracellular