The Effect of Aspirin and Prostaglandin E1 on the Patency of Microvascular Anastomosis in Rat

백서에서 Aspirin과 Prostaglandin E1이 미세혈관 문합의 개존에 미치는 효과

  • Lee, Kwang Suk (Department of Orthopedic Surgery, Korea University Hospital) ;
  • Suh, Jeong Dae (Department of Orthopedic Surgery, Korea University Hospital) ;
  • Han, Seung Beom (Department of Orthopedic Surgery, Korea University Hospital) ;
  • Lee, Seung Joon (Department of Orthopedic Surgery, Korea University Hospital) ;
  • Choi, In Chul (Department of Orthopedic Surgery, Korea University Hospital) ;
  • Kim, In Sun (Department of Pathology, Korea University Hospital) ;
  • Cho, Seong Jin (Department of Pathology, Korea University Hospital)
  • 이광석 (고려대학교 의과대학 정형외과학교실) ;
  • 서정대 (고려대학교 의과대학 정형외과학교실) ;
  • 한승범 (고려대학교 의과대학 정형외과학교실) ;
  • 이승준 (고려대학교 의과대학 정형외과학교실) ;
  • 최인철 (고려대학교 의과대학 정형외과학교실) ;
  • 김인선 (고려대학교 의과대학 병리학교실) ;
  • 조성진 (고려대학교 의과대학 병리학교실)
  • Published : 2000.10.31

Abstract

In the field of microsurgery, the vascular obstruction of the microvascular anastomosis by thrombus is one of the most important complication. The purpose of this study is to compare the effect between aspirin and prostaglandin $E_1$($PGE_1$) which act as the peripheral vasodilatation and platelet disaggregation. We have used total 48 white male rats and divided them into three gruoups(A, B and C group). Each group consists of 16 rats respectively. A group is as control, B group is medicated with aspirin(3.0mg/kg/day) and C group with $PGE_1(1.2{\mu}g/kg/day)$. The gross and histopathologic findings at anastomosed site were observed on 3, 5, 10 and 15 days after vascular anastomosis and the results were obtained as the followings. 1. The microvascular patency rate is 81.2% in control group, 93.8% in aspirin group and 100% in $PGE_1$ group. 2. On the histologic examination, the formation of mural thrombus is decreased both in the aspirin and $PGE_1$ group as comparing with the control group and also the hypertrophy of the intima forming from media is less formed in $PGE_1$ group than aspirin group and the degree of thickeness is also less. 3. The fibrosis of media is less observed in $PGE_1$ group than aspirin group. According to the above results, the application of $PGE_1$ to the microsurgery is considered to be effective on the prevention of the thrombus formation and on providing high patency rate.