Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Cytotoxicity and Antimicrobial Effect of the Extract of Salvia plebeia

배암차즈기 추출물의 세포독성과 항균효과

  • Shin, Min-Kyo (Department of Herbalogy, School of Oriental Medicine, Wonkwang University) ;
  • Kim, Seok-Keun (Department of Herbalogy, School of Oriental Medicine, Wonkwang University) ;
  • Lee, Sang-kon (Department of Herbalogy, School of Oriental Medicine, Wonkwang University) ;
  • Gang, Yeong-Seong (Department of Herbalogy, School of Oriental Medicine, Wonkwang University) ;
  • Kim, Seong-Su (Department of Herbalogy, School of Oriental Medicine, Wonkwang University) ;
  • Yang, Eun-Yeong (Kunhil Pharmaceutical Co., LTD.) ;
  • Lee, Hyun-Ok (Department of Dental Hygiene, Wonkwang Public Health) ;
  • Baek, Seung-Hwa (Department of Natural Products, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 신민교 (원광대학교 한의과대학 본초학교실) ;
  • 김석근 (원광대학교 한의과대학 본초학교실) ;
  • 이상건 (원광대학교 한의과대학 본초학교실) ;
  • 강영성 (원광대학교 한의과대학 본초학교실) ;
  • 김성수 (원광대학교 한의과대학 본초학교실) ;
  • 양은영 (건일제약(주) 중앙연구소) ;
  • 이현옥 (원광보건대학 치위생과) ;
  • 백승화 (원광대학교 한의과전문대학원 천연물학교실)
  • Published : 2001.03.30
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Abstract

The comparison of $IC_{50}$ values of Salvia plebeia R. Br. extracts on L1210, $P388D_1$ cancer and Vero normal cell lines showed that the n-hexane soluble extract of S. plebeia R. Br. retains the most growth-inhibitory activity against tumor cell lines. The minimum inhibitory concentration (MIC) of the extract against microorganisms were also examined. Antimicrobial activity of amocla and ketoconazole as references was compared to those of other solvent extracts such as $H_2O$, n-hexane, chloroform, ethyl acetate and methanol. The antimicrobial activity of extract had growth inhibition activity against gramnegative bacteria, gram-positive bacteria and fungi $(MIC\;>\;200\;{\mu}g/ml)$ except for n-hexane extract. Seven bacterial strains were tested for in vitro susceptibility to the extract of S. plebeia R. Br. However the n-hexane extract of S. plebeia R. Br. inhibited the growth of several bacterial strains (MIC values between 100 and $200\;{\mu}g/ml$ for gram positive bacteria, $25\;{\mu}g/ml$ for P. putida).

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