Korean Journal of Pharmacognosy (생약학회지)
- Volume 32 Issue 1 Serial No. 124
- /
- Pages.22-30
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- 2001
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- 0253-3073(pISSN)
- /
- 2288-9299(eISSN)
Studies on the Development of Antihyperlipidemic Drugs from Oriental Herbal Medicines (III) -Antihyperlipidemic Effects of Gamigwaruhaebaekwhanggum-Tang and Its Constituent Herbal Medicines in vitro-
한방약물로부터 항고지혈증 치료약물개발(3) -In vitro에서 가미과루해백황금탕 및 구성약물의 항고지혈증 활성-
- Jung, Eun-Ah (East-West Medical Research Institute, Kyung-Hee University) ;
-
Kim, Yun-Kyung
(College of Oriental Medicine, Kyung-Hee University)
;
-
Kim, Dong-Hyun
(College of Pharmacy, Kyung-Hee University)
;
- Lee, Sang-In (College of Oriental Medicine, Kyung-Hee University) ;
-
Kim, Nam-Jae
(East-West Medical Research Institute, Kyung-Hee University)
- 정은아 (경희대학교 동서의학연구소) ;
-
김윤경
(경희대학교 한의과대학)
;
-
김동현
(경희대학교 약학대학)
;
- 이상인 (경희대학교 한의과대학) ;
-
김남재
(경희대학교 동서의학연구소)
- Published : 2001.03.30
Abstract
80% extract of Gamigwaruhaebaekbaekju-Tang (GGHBT), Gagamgwaruhaebaekbaekju-Tang (GGGHBT) and Gamigwaruhaebaekwhanggum-Tang (GGHWT) remarkably showed inhibitory effects on HMG-CoA reductase, lipid peroxidation of rat liver and LDL oxidation, and DPPH free radical scavenging effect in a dose-dependent manner. Especially, GGHWT which is formulated with Trichosanthis Fructus, Pinelliae Tuber, Aurantii Immatures Fructus, Magnoliae Cortex, Allii Macrostemi Bulbus, Cinnamomi Ramulus and Scutellariae Radix on the basis of Gwaruhaebaekbaekiu-Tang listed on the traditional medicinal references showed more effective hypocholesterolemic activities in vitro bioassay than the other prescriptions.
Keywords
- Gamigwaruhaebaekwhanggum-Tang;
- HMG-CoA reductase;
- lipid peroxidation;
- LDL oxidation;
- antioxidant;
- hypocholesterolemic effect;
- DPPH free radical