Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지

Modulation of Cyclic AMP-PKA System on Inhibitory and Excitatory Herbs-induced Ion Currents

Cyclic AMP-PKA System이 억제성 및 흥분성 한약재에 의해 유발된 이온전류에 미치는 영향

  • Kim Youn-Jung (Dept. of Physiology, College of Medicine, Kyung Hee University) ;
  • Shin Min-Chul (Dept. of Physiology, College of Medicine, Kyung Hee University) ;
  • Chung Joo-Ho (Dept. of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Lee Choong-Yeol (Dept. of Physiology, College of Oriental Medicine, Kyung Won University) ;
  • Kim Ee-Hwa (Dept. of Physiology, College of Oriental Medicine, Se Myung University) ;
  • Kim Chang-Ju (Dept. of Physiology, College of Medicine, Kyung Hee University)
  • 김연정 (경희대학교 의과대학 생리학교실) ;
  • 신민철 (경희대학교 의과대학 생리학교실) ;
  • 정주호 (경희대학교 의과대학 약리학교실) ;
  • 이충열 (경원대학교 한의과대학 생리학교실) ;
  • 김이화 (세명대학교 한의과대학 경혈학교실) ;
  • 김창주 (경희대학교 의과대학 생리학교실)
  • Published : 2001.03.27
Download PDF
⟨ Previous Next ⟩

Abstract

Modulatory effect of cAMP-PKA system on inhibitory- and excitatory herbs-induced ion currents were investigated by nystatin-perforated patch clamp method under voltage-clamp condition. Ion currents induced by Bupleuri radix and Coptidis rhizoma were not affected by cAMP-PKA system. Ion current induced by Ecliptae herba was partially inhibited by cAMP-PKA system. Ion currents induced by Aconiti tuber and Boshniakiae herba were inhibitory modulated and ion current induced by Zingiberis rhizoma was excitatory modulated by cAMP-PKA system. Modulation of cAMP-PKA system on ion currents induced by Ginseng radix was fluctuated. In this results, it can be seen generally that excitatory herbs-induced ion currents were modulated by cAMP-PKA system while cAMP-PKA system did not affect inhibitory herbs-induced ion currents.

Keywords

References

  1. 동의생리학회지 v.6 no.1 혈액학적 지표를 이용한 기아상태의 음양론적 해석에 대한 실험적 연구 김원종;김완희
  2. 동의학의 방법론 연구 v.28 윤길영
  3. 동의생리학회지 v.6 no.1 기아상태의 음양론적 해석에 대한 실험적 연구-내분비 지표를 중심으로 이충열;홍무창;김완희
  4. 中醫基礎理論現代硏究 陳達理;周立紅(編)
  5. Neuroscience v.56 Proten kinase A-mediated phosphorylation reduces only the fast desensitizing glycine current in acutely dissociated ventromedial hypothalamic neurons Agopyan N;Tokutomi N;Akaike N
  6. Proc Natl Acad Sci USA v.87 Protein kinase C and cAMP-dependent protein kinase phosphorylate the ${\beta}$-subunit of the purified GABA receptor Browning MD;Bureau M;Duck EM;Olsen RW
  7. Neuron. v.7 Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by ${\mu}$ opioid Chen L;Huang L-Y M
  8. J Cell Biol. v.100 Agents that activate protein kinase C reduce acetylcholine sensitivity in cultured myotubes Eusebi F;Molinaro M;Zani BM
  9. Neurosci Lett. v.263 The fast activating potassium current, I(K,f), guinea-pig inner hair cells is regulated by protein kinase A Jagger DJ;Ashmore JF
  10. J Neurophysiol. v.77 Modulation of high-voltage activated $Ca^2+$ channels in the rat periaqueductal gray neurons by ${\mu}$-type opioid agonist Kim CJ;Rhee JS;Akaike N
  11. Brain Res. v.734 Modulation of glycine-induced chloride current in acutely dissociated rat periaqueductal gray neurons by ${\mu}$-opioid agonist, DAGO. Min BI;Kim CH;Rhee JS;Akaike N
  12. Neuroscience v.89 Alpha2-adrenoceptor-mediated enhancement of glycine response in rat sacral dorsal commissural neurons Nabekura J;Xu TL;Rhee JS;Akaike N
  13. Neuron. v.5 Cyclic AMP-dependent protein kinase decreases $GABA_A$ receptor current in mouse spinal neurons Porter NM;Twyman RE;Uhler MD;Macdonald RL
  14. Brain Res. v.811 cAMP-dependent protein kinase modulation of glycine-activated chloride current in neurons freshly isolated from rat ventral tegmental area Ren J;Ye JH;McArdle JJ
  15. Cell Physiology Ion channels that are directly regulated by G proteins Yatani A