Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The Effect of Guibiondamtang(歸脾溫膽湯) in an Animal Model of Depression using Chronic Mild Stress

우울증(憂鬱症) 모델 흰쥐에 대한 귀비온담탕(歸脾溫膽湯)의 실험적(實驗的) 연구(硏究)

  • Kim Jong-Woo (Dept. of Oriental Neuropsychiatry, Kyung Hee University) ;
  • Whang Wei-Wan (Dept. of Oriental Neuropsychiatry, Kyung Hee University) ;
  • Kim Hyun-Taek (Dept. of Psychology, Korea University) ;
  • Kwak So-Young (Dept. of Psychology, Korea University) ;
  • Kim Min-Jung (Dept. of Psychology, Korea University) ;
  • Cha Yun-Ju (Dept. of Oriental Neuropsychiatry, Kyung Hee University)
  • 김종우 (경희대학교 한의과대학 신경정신과) ;
  • 황의완 (경희대학교 한의과대학 신경정신과) ;
  • 김현택 (고려대학교 심리학과) ;
  • 곽소영 (고려대학교 심리학과) ;
  • 김민정 (고려대학교 심리학과) ;
  • 차윤주 (경희대학교 한의과대학 신경정신과)
  • Published : 2001.12.30
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Abstract

This study was performed to investigate the anti-depression effect of Guibiondamtang in rat model of depression. The rats in the experiment were stratified into 3 groups, ie, Guibiondamtang, saline, normal (non-stressed) groups. Chronic exposure to mild unpredictable stress such as white noise, flashing lights and restriction of food and water, causes the behavioral symptoms correspondent to depression. Consumption of 1% sucrose solution fell in rats exposed to CMS for 4 weeks. In the open field test , the exploratory activity ie. locomotion and centering decreased after CMS. We then evaluated the sucrose consumption and activity during 4 weeks of treatment with experimental drugs. The results were as follows: 1) There was no relation between sucrose intake and weight. 2) The Guibiondamtang(歸脾溫膽湯) group reinstated sucrose consumption within 5-6 weeks while having no influence on sucrose intake in normal group. 3) The Guibiondamtang(歸脾溫膽湯) group restored some exploratory activity in the open field test. 4) The Guibiondamtang-group had a-reduced potentiated startle response.

Keywords

References

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