Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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Effects of auricular acupuncture on neuronal activities in the brain of sprague dawley rats

이침(耳鍼)이 절식(絶食)시킨 흰쥐의 뇌신경세포(腦神經細胞) 활성변화(活性變化)에 미치는 영향(影響)

  • Kim, Ee-Hwa (Department of Meridianology, College of Oriental Medicine, Se-Myung University) ;
  • Kim, Youn-Jung (Koh-Wang Medical Research Institute, Kyung-Hee University) ;
  • Lim, Baek-Vin (Koh-Wang Medical Research Institute, Kyung-Hee University) ;
  • Jang, Mi-Hyun (Koh-Wang Medical Research Institute, Kyung-Hee University) ;
  • Chung, Joo-Ho (Koh-Wang Medical Research Institute, Kyung-Hee University) ;
  • Kim, Chang-Ju (Koh-Wang Medical Research Institute, Kyung-Hee University)
  • 김이화 (세명대학교 한의과대학 경혈학교실) ;
  • 김연정 (경희대학교 고황의학연구소) ;
  • 임백빈 (경희대학교 고황의학연구소) ;
  • 장미현 (경희대학교 고황의학연구소) ;
  • 정주호 (경희대학교 고황의학연구소) ;
  • 김창주 (경희대학교 고황의학연구소)
  • Received : 2001.01.04
  • Accepted : 2001.01.15
  • Published : 2001.02.20
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Abstract

Objective : The aim of this study was to investigate the effectiveness of stimulation of specific auricular acupuncture points on appetite suppression. Methods : The fasted rats were deprived of food and water for 48 hours. Stimulation of tho inner auricular region of the rat correspond to the human stomach acupuncture point was made for leptin, tryptophan hydroxylase (TPH) and c-fos expression in the brain of the fasted rats by immunohistochemistry. Results : The immunoteactivities of leptin in the periventricular nucleus of the auricular acupunctured group with fasted were significantly higher compared to those of the fasted group. The immunoreactivities of TPH in the median raphe neucleus and reticulotegmental neucleus pons of the auricular acupunctured group with fasted were significantty higher compared to those of the fasted group. And the immunoreactivities of c-fos in the dentate gyrus of the auricular acupunctured group with fasted were significantly lower compared to those from the fasted group. Conclusions : We conclude that the auricular acupuncture altered leptin and TPH-expression in the brain of the fasted rats. The results suggest that auricular acupuncture may inhibit food intake.

Keywords

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