Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Enhancement of Anticancer Activity by Combination of Garlic (Allium sativum) Extract and Vitamin C

마늘 추출물과 비타민 C 혼합물에 의한 암세포증식억제의 상승 효과

  • 황우익 (고려대학교 의과대학 생화학교실) ;
  • 손향은 (고려대학교 의과대학 생화학교실) ;
  • 이지영 (고려대학교 부설 한국영양문제연구소) ;
  • 김동청 (순천제일대학 식생활과)
  • Published : 2001.04.01
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Abstract

The effect of garlic extract and vitamin C mixture on the various cancer cell lines in vitro and in vivo have been examined. Proliferation of human colon cancer (HT-29), human rectal cancer (HRT-18) and human hepatoma (HepG2) cells was inhibited by garlic extract and vitamin C, respectively. Based on the cytotoxic activity, mixture of garlic extract and vitamin C was demonstrated to possess a synergistic growth inhibition on HT-29, HRT-18 and HepG2 cancer cells. Mixture of garlic extract and vitamin C significantly arrested G2/M phase cells in the HepG2 cell cycle. Oral administration of mixture of garlic extract and vitamin C to sarcoma-180 tumor-bearing mice prolonged survival time compared to that of control group. These results suggested that addition of vitamin C enhances anticancer activity of garlic extract in vitro, and mixture of garlic extract and vitamin C has antitumor effect in vivo.

Keywords

References

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