Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effect of Fiber-Rich Sea Mustard Feeding on AOM-Induced Colon Aberrant Crypt Formation and Colonic Cell Proliferation in Sprague Dawley Rats

미역의 섭취가 화학적으로 유도된 쥐의 대장암화 표지자인 Aberrant Crypt 형성 및 상피세포 분열에 미치는 영향에 관한 연구

  • 이은주 (숙명여자대학교 식품영양학과) ;
  • 성미경 (숙명여자대학교 식품영양학과)
  • Published : 2001.06.01
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Abstract

The modulating effect of feeding sea mustard (Undarina pinnatifida), a fiber-rich seaweed, during initiation and post-initiation phases of colon carcinogenesis was investigated in Sprague Dawley rats. Four groups of animals were exposed to the two weekly injections of a chemical carcinogen, azoxymethane (AOM). Animals were placed on diet containing 15% sea mustard during initiation. post-initiation or initiation+post-initiation phase of carcinogenesis for 10 weeks, and colonic aberrant crypt formation and cell proliferation were compared to those of rats fed semi-synthetic control diet. Results showed that sea mustard feeding significantly reduced the numbers of both aberrant crypts and aberrant crypt foci. Also, labeling indices and proliferation zones were significantly reduced in the colon of the rats fed sea mustard diets. These results indicate that the diet containing sea mustard may decrease the risk of colon cancer development, and a part of such effect may be mediated through both the blocking of initiation and the suppression of cell proliferation in the colonic crypts, although precise mechanisms should be further examined.

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References

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