Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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A Preliminary Study on the Hypoglycemic Effect of the Exo-Polymers Produced by Five Different Medicinal Mushrooms

  • Published : 2001.02.01
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Abstract

The Hypoglycemic effect of exo-polymers (EPs) produced from submerged mycelial cultures of five types of mushrooms on streptozotocin (STZ)-induced diabetic rats were investigated in this study. The five experimental groups were fed with EPs (50 mg/kg body weight) for 7 days. Significant reduction in plasma glucose, total cholesterol (TC), and triglyceride (TG) levels were observed in rats fed with Lentinus edodes and Cordyceps militaris EPs. Plasma glucose and TC were also reduced by administration of Phellinus linteus EPs, but the TG level was not changed significantly. The EPs of three mushroom species also demonstrated a marked reduction in the level of plasma glutamate-pyruvate transminase (GPT). The result proves the hypoglycemic activity of EPs of three fungal group in STZ-induced diabetic rats and indicates their potential in the control of diabetes mellitus.

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