Journal of Ginseng Research
- Volume 25 Issue 4
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- Pages.141-149
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- 2001
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- 1226-8453(pISSN)
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- 2093-4947(eISSN)
A Protective Effect for Panax ginseng in the Rat Stomach
- Omar M.E.Abdel Salam (Department of Pharmacology, National Research Centre) ;
- Batran, Seham-El (Department of Pharmacology, National Research Centre) ;
- Shenawy, Siham-El (Department of Pharmacology, National Research Centre) ;
- Mahmoud S.Arbid (Department of Pharmacology, National Research Centre)
- Published : 2001.12.01
Abstract
The effect of ginseng on gastric ulcer and gastric acid secretion was investigated in pylorus-ligated rats. Methods: Sprague-Dawley strain rats were used after 24 hours fast. Pylorus-ligation was performed under light ether anaesthesia, then gastric mucosal damage was evoked in conscious pylorus-ligated rats by the administration of subcutaneous (s.c.) indomethancin (20mg/kg), s.c. histamine (150mg/kg) or by pylorus-ligation (Shay ulcer). Ginseng was given by intragastric (i.g.) or intraperitoneal (i.p.) route simultaneously with the ulcerogens. Rats were killed after 3h (indomethacin) and histamine models) or after 18h (Shay ulcer), when the gastric secretory responses, the number and severity of gastric mucosal lesions and mucosal mucus content deetermined. the effect of i.p. ginseng on basal gastric acid secretion and on gastric acide secretion in indomethacin (20mg/kg, s.c.)-treated rats was also investigated in urethane anesthetized rats. Gastric acid secretion was measured by flushing of the gastric lumen with saline every 15min through an oesophageal cannula. Results: In conscious pylorus-ligated rats, i.g. ginseng(12.5-50mg/