Journal of Environmental Health Sciences (한국환경보건학회지)
- Volume 27 Issue 3
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- Pages.63-70
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- 2001
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- 1738-4087(pISSN)
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- 2233-8616(eISSN)
Carcinogen-DNA adducts in Liver and Bladder of Sprague-Dawley rats treated with benzidine in drinking water
벤지딘으로 오염된 음용수를 섭취한 흰쥐에서 간장세포와 방광세포에 형성된 발암물질- DNA adduct에 관한 연구
Abstract
To identify and evaluate the benzidine-DNA adducts in liver and bladder, we exposed the 80 ppm benzidine to 40 sprague-dawley rats by drinking water for 4 weeks(6.2 mg/kg body wt./day). Only one benzidine-DNA adduct was found at the same site of thin layer chromatogram of
Keywords
- Benzidine;
- DNA adduct;
- N-(deoxyguanosin-8-yl)-N′-acetylbenzidine;
- Relative adduct labeling(RAL);
- Liver;
- Bladder