Biotechnology and Bioprocess Engineering:BBE

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Thermocontrol of Solute Permeation across Polymer Memberane Composed of Poly(N, N-dimethylaminoethyl methacrylate) and Its Copolymers

  • Yuk, Soon-Hon (Department of Polymer Science and Engineering Hannam University, Taejeon 306-791) ;
  • Cho, Sun-Hang (Advanced Materials Division , Korea Research of Chemical Technology, Taejeon 305-600)
  • Published : 2001.07.01
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Abstract

Polymer membranes composed of N, N-dimethylaminoethyl methaccrylate(DMAEMA) and acrylamide(AAm)(or ethyl acrylamide(EAAm) were prepared to demonstrated the thermo-control of solute permeation. Poly DMEMA has a lower critical solution temperature(LCST) at around 50$\^{C}$ in water, With the copolymerization of DMAEMA with AAm (or EAAm) a shift in the LCST to a lowere temperature was observed, probably due to the formation of hydrogen bonds between the amide and N-N-dimethylamino groups. However, the temperature-induced phase transition of poly(DMAEMA-co-EAAm) did not show a similar trend to that of poly(DMAEMA- co-AAm) in the gel state. The hydrogen bonds in poly(DMAEMA-co-EAAm) were significantly disrupted with the formation a gel network, which led to a difference in the swilling behavior of polymer gels in response to temperature. To apply these polymers to temperature-sensitive sol-ute permeation, polymer membranes were prepared. The permeation pattern of hydrocortisone, used as the model solute, was explained based on the temperature-sensitive swelling behavior of the polymer membranes.

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References

  1. J. Macromol. Sci.-Chem. v.A2 no.8 Solution properties of poly (NIPAAm) Heskins, M.;J. E. Guillet
  2. J. Contr. Rel. v.4 Thermally reversible hydrogels: Ⅲ. Immobilization of enzymes for feedback reaction control Dong, L. C.;A. S. Hoffman
  3. Makromol. Chem. Rapid Commun. v.8 Thermosensitive polymers as on-off switches for drug release Bae, Y. H.;T. Okano;S. W. Kim
  4. Polymer v.29 Dynamic pH-dependent swelling properties of a hydrophobic polyelectrolyte gel Firestone, B. A.;R. A. Siegel
  5. Macromolecules v.17 Swelling of ionic Gels: Quantitative performance of the Donnan theory Ricka, J.;T. Tanaka
  6. Nature v.354 Electrically erodible polymer gel for controlled release of drugs Kwon, I. C.;Y. H. Bae;S. W. Kim
  7. J. Contr. Rel. v.7 Surface instabilities during swelling of pH-sensitive hydrogels Drummond, W. R.;M. L. Knight;M. L. Brannon;N. A. Peppas
  8. Macromolecules v.25 Mutual influence of pH and temperature on the swelling of ionizable and thermosensitive hydrogels Feil, H.;Y. H. Bae;J. Feijen;S. W. Kim
  9. Nature v.373 Graft copolymers that exhibit temperature-induced phase tranistions over a wide range of pH Chen, G. H.;A. S. Hoffman
  10. Nature v.349 Volume transition in a gel driven by hydrogen bonding Ilman, F.;T. Tanaka;E. Kokufuta
  11. Macromolecules v.27 Temperature-responsive interpenetrating polymer networks constructed with poly(acrylic acid) and poly(N,N-dimethylacrylamide) Aoki, T.;M. Kawashima;M. Katono;K. Sanui;N. Ogata;T. Okano;Y. Sakurai
  12. J. Polym. Sci. B: Polym. Phys. v.35 Temperature-induced phase tranistion of poly(N,N-dimethylaminoethyl methacrylate-co-acrylamide) Cho, S. H.;M. S. Jhon;S. H. Yuk;H. B. Lee
  13. Macromolecules v.30 pH/temperature-responsive polymer composed of poly((N,N-dimethylamino)ethyl methacrylate-co-acrylamide) Yuk, S. H.;S. H. Cho;S. H. Lee
  14. Intelligent Materials for Controlled Release Temperature-Sensitive Polymer System Constructed with Sodium Alginate and Poly(N,N-dimethylamino-ethyl methacrylate-co-acrylamide) Yuk, S. H.;S. H. Cho;H. B. Lee;M. S. Jhon;S. V. Dinh(ed.);J. D. DeNuzzio(ed.);A. R. Comfort(ed.)
  15. Eur. Polym. J. v.35 Temperature-sensitive swelling behavior of polymer gel composed of poly(N,N-dimethylaminoethyl methacrylate) and its copolymers Cho, S. H.;M. S. Jhon;S. H. Yuk