Journal of Microbiology

The Microbiological Society of Korea (한국미생물학회)
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Association of a Provisional New emm Type Opacity Factor-Negative Group A Streptococci Strain ST4529 with Septicemia

  • R.R. Rantty (Department of Biochemistry and Microbiology) ;
  • M. Eshaghi (Department of Biotechnology) ;
  • A.M. Ali (Department of Biotechnology) ;
  • F. Jamal (Department of Clinical Laboratory Science, Universiti Putra Malaysia) ;
  • K. Yusoff (Department of Biochemistry and Microbiology)
  • Published : 2001.09.01
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Abstract

Group A Streptococcus strain ST4529 is a provisional new ems type which has been recently reported in Malaysia (Jomal, et al. 1999. Energ. Infect . Dis. 5,10-14). This strain was found to be opacity factor (OF) negative with a Tl phenotype. Usually, OF negative strains with T1 phenotypes are associated with acute rheumatic fever. However, strain ST4529 was isolated from the blood of a patient with septicemia. Comparison of the deduced amino acid sequence of the mature hypervariable N-terminus of ST4529 showed only 43% identity with that of M5, the closest matched OF negative strain with a T1 phenotype. Thus, ST4529 most probably encodes a new serospecifically unique M protein which is associated with septicemia rather than pharyngitis infections. The strains with these phenotypes are very important because their sequences should be considered for developing any anti-streptococcal vaccines.

Keywords

References

  1. Microbiol. v.146 emm and sof gene sequence variation in relation to serological typing of opacity-factor-positive group A streptococci Beall B.;G.Gherardi;M.Lovgren;R.R.Facklam;B.A.Forwick;G.J.Tyrrell
  2. J.Med.Microbiol. v.45 Analysis of genetic relationships among strains of group A,C and G streptococci by random amplified polymorhic DNA analysis Bert F.;B.Picard;C.Branger;N.Lambert-Zechovsky
  3. J.Exp.Med. v.169 Evidence for two distinct classes of streptococcal M protein and their relationship to rheumtic fever Bessen D.;K.F.Jones;V.A.Fischetti
  4. New England Medical v.325 Group A streptococcal infections and acuterheumatic fever Bisno A.L.
  5. Emerg.Infect.Dis. v.5 emm typing and validation of provisional M types for group A streptococci Facklam R.;B.Beall;A.Efstratiou;V.Fischetti;D.Johnson;E.Kaplan;P.Kriz;M.Lovgren;D.Martin;B.Schwartz;A.Totolian;D.Bessen;S.Hollingshead;F.Rubbin;J.Scott;G.Tyrrell
  6. Mol.Microbiol. v.4 Conservation of hexapeptide sequence in the anchor region of surface protein from gram-positive cocci Fischetti V.A.;V.Pancholi;O.Schneewind
  7. J.Clinic.Microbiol. v.34 Molecular epidemiology of impetiginous group A streptococcal infections in Aboriginal communities of Northen Australia Gardiner D.L.;K.S.Spiprakash
  8. J.Bacteriol. v.174 Architecture of the Vir regulons of group A streptococci parallels opacity factor phenotype and M protein class Haanes E.J.;D.G.Heath;P.P.Cleary
  9. Emerg.Infect.Dis. v.5 New emm(M protein gene) sequences of group A streptococci isolated from Malaysian patients Jamal F.;S.Pit;R.Facklam;B.Beall
  10. J.Clin.Microbiol. v.26 Microtechnique for serum opacity Factor characterization of group A streptococci adaptable to the use of human sera Johnson D.R;E.L.Kaplan
  11. J.Infect.Dis. v.166 Genetic diversity in T1M1 group A streptococci in relation to clinical outcome of infection Norgren M.;A.Norrby;S.E.Holm
  12. Med.Microbiol.Immunol. v.180 Application of the polymerase chain reaction to study the M protein(-like-) gene family in beta-haemolytic streptococci Podbielski A.;B.Melzer;R.Lutticken
  13. Mol.Microbiol. v.11 Horizontal gene transfer in the evolution of group A streptococcal emm-like genes: gene mosaics and variation in Vir regulons Whatmore A.M;M.A.Kehoe
  14. Mol.Microbiol. v.14 Non-congruent relationships between variation in emm gene sequences and the population genetic structure of group A streptococci Whatmore A.M;V.Kapur;D.J.Sullivan;J.M.Musser;M.A.Kehoe
  15. J.Exp.Med. v.162 Inhibition of complement-mediated opsonisation and phagocytosis of Streptococcus pyogenes by D fragments of fibrinogen and fibrin bound to cell surface M protein Whitnack E.;E.H.Beachey