약학회지 (YAKHAK HOEJI)

  • 제45권5호
  • /
  • Pages.500-505
  • /
  • 2001
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

천연물로부터의 세포내 효소 활성 조절물질의 탐색 및 기능 연구: 갈근의 알코을 탈수소효소 저해 활성 성분

Studies on the Screening of Bioactive Compound Acting on Intracellular Enzymes from Natural Products and Its Mode of Action : Inhibitory Component of Puerariae Radix on Alcohol Dehydrogenase Activity

  • 이현주 (이화여자대학교 약학대학 · 약학연구소) ;
  • 오민아 (이화여자대학교 약학대학 · 약학연구소) ;
  • 최영희 (이화여자대학교 약학대학 · 약학연구소) ;
  • 이강만 (이화여자대학교 약학대학 · 약학연구소)
  • 발행 : 2001.10.01
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초록

Puerariae Radix is one of the medicinal plants used in oriental medicine for hangover, It has been claimed for several pharmacological effects including anti-alcohol abuse, antidipsotropic activity and anti-alcohol intoxication. In connection with Puerariae Radix effects, an activity-guided purification of active substance on alcohol dehydrogenase (hnH) was carried-out. The most active compound was isolated as puerarin (C$_{21}$H$_{20}$ O$_{9}$ ), molecular weight 416. Puerarin inhibited ADH noncompetitively against ethanol or NAD$^{+}$./.

키워드

참고문헌

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  9. 현대생약학 생약연구회 저
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