Archives of Pharmacal Research
- Volume 24 Issue 1
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- Pages.27-34
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- 2001
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and Preliminary Antimicrobial Screening of New Benzimidazole Heterocycle
- Fahmy, H.H. (Therapeutical Chemistry Dept., National Research Centre) ;
- El-masry, A.Ali Abdelsahed, S.H. (Therapeutical Chemistry Dept., National Research CentreTherapeutical Chemistry Dept., National Research Centre)
- Published : 2001.02.01
Abstract
A series of 2-methylbenzimidazole incorporated to different heterocycles through ethyl or carbamoylethyl groups at position 1 of benzimidazole were synthesized. Also 3-(2-methylbenzimidazol-1-yl)propanoic acid hydrazide incorporated with semicarbazides and thiosemicarbazides were prepared. Moreover, the triazole 5e underwent Michael addition and alkylation reaction. Some of the newly synthesized compounds showed considerable antimicrobial activity against gram positive, negative bacteria and yeast.
Keywords
- Semicarbazides;
- Thiosemicarbazides;
- Thiadiazole;
- Thiazoline;
- Thiazolidinone;
- Triazole;
- Michael addition;
- Alkylation reaction