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Synthesis and SAR of Benzimidazole Derivatives Containing Oxycyclic Pyridine as a Gastric $H^+/K^+$-ATPase Inhibitors


초록

A series of benzimidazole derivatives containing oxycyclic pyridine was prepared and evaluated for their gastric H+ /K+ -ATPase inhibitory activity. Several of the synthesized compound exhibited potent antisecretion in pylorus-ligated rats when administered intradoudenally. Their inhibitory activities were equivalent or comparable to omeprazole.

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참고문헌

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피인용 문헌

  1. ChemInform Abstract: Synthesis and SAR of Benzimidazole Derivatives Containing Oxycyclic Pyridine as a Gastric H+/K+-ATPase Inhibitors. vol.33, pp.29, 2001, https://doi.org/10.1002/chin.200229162
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