Treatment of Henoch-Sch$\ddot{o}$nlein Purpura with Intravenous Immunoglobulin

  • Chung, Hyo-Seok (Department of Pediatrics, College of Medicine, Yeungnam University) ;
  • Kim, Won-Duck (Department of Pediatrics, College of Medicine, Yeungnam University) ;
  • Lee, Eun-Sil (Department of Pediatrics, College of Medicine, Yeungnam University) ;
  • Choi, Kwang-Hae (Department of Pediatrics, College of Medicine, Yeungnam University) ;
  • Park, Yong-Hoon (Department of Pediatrics, College of Medicine, Yeungnam University) ;
  • Kim, Yong-Jin (Department of Pathology, College of Medicine, Yeungnam University)
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  • 박용훈 (영남대학교 의과대학 소아과학교실) ;
  • Received : 2001.11.15
  • Accepted : 2001.12.18
  • Published : 2001.12.30

Abstract

We report the result of a high-dose intravenous immunoglobulin therapy in a Henoch-Schnlein purpura patient with severe abdominal pain and nephrotic syndrome who did not respond to methylprednisolone pulse therapy. Kidney biopsy showed diffuse mesangial cell proliferative glomerulonephritis with fibrocellular crescent formation in approximately 50% of glomeruli. Mesangium of all glomeruli were strong positive for IgA and C3 antibodies. High-dose intravenous immunoglobulin treatment was introduced and dramatic improvement of gastrointestinal symptom and proteinuria as well as hematuria was noted. Immunoglobulin administration should be considered in Henoch-Schnlein purpura patients with steroid-resistant intractable gastrointestinal manifestation and renal involvement.