Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis and Preliminary Biological Studies of Novel Retinamide Derivatives

  • Sin, Hong-S. ;
  • Kwon, Youn-J. ;
  • Han, Hye-S. ;
  • Park, Si-H. ;
  • Park, Moong-S. ;
  • Rho, Young-S. ;
  • Um, Soo-J.
  • Published : 2002.12.20
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Abstract

We have described the synthesis and biological activity of novel retinamide . The retinamide derivatives were synthesized by introducing functional side chains into the 4-hydroxy group of 4-HPR. The activities could be dependent on the side chain length, functional group, and hetero atom. The antiprolife-rative potential of the derivatives was assessed by MTT assay in HCT116 cancer cell lines.

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References

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