Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The Effects of Quibitang in the Chronic Mild Stress Model of Depression in Rats

우울증유발(憂鬱症誘發) 흰쥐에 대한 귀비양(歸脾揚)의 항우울효과(抗憂鬱效果)

  • Seong, Woo-Yong (Dept. Oriental Neuropsychiatry, College of Oriental Medicine, Kyung Hee University) ;
  • Whang, Wei-Wan (Dept. Oriental Neuropsychiatry, College of Oriental Medicine, Kyung Hee University) ;
  • Park, Eun-Hye (Dept. Psychology, Korea University) ;
  • Lee, Jung-Ryun (Dept. Psychology, Korea University) ;
  • Kim, Hyun-Taek (Dept. Psychology, Korea University) ;
  • Kim, Jong-Woo (Dept. Oriental Neuropsychiatry, College of Oriental Medicine, Kyung Hee University)
  • 성우용 (경희대학교 한의과대학 한방신경정신과학) ;
  • 황의완 (경희대학교 한의과대학 한방신경정신과학) ;
  • 박은혜 (고려대학교 심리학과) ;
  • 이정륜 (고려대학교 심리학과) ;
  • 김현택 (고려대학교 심리학과) ;
  • 김종우 (경희대학교 한의과대학 한방신경정신과학)
  • Published : 2002.12.31
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Abstract

This study was performed to evaluate the effects of Quibitang in the chronic mild stress(CMS) model of depression in rats. Chronic exposure to mild unpredictable stress was found to depress the consumption of sucrose solution in rats for 8 weeks. These CMS-treated rats were stratified into Quibitang gruop and saline group. And control rats were also stratified into Quibitang group and saline group. The change of the consumption of sucrose solution and the body weight were measured, and open field test, elevated startle response and plus maze test were performed, to investigate the anti-depression effect of Quibitang. The results were as follows: 1. The consumption of sucrose solution was significantly reversed in Quibitang-treated group at 9th, 11th, 12th week, but there was no significant change at 10th week 2. CMS schedule decreased body weight. CMS-treated groups showed decrease of body weight after 5 weeks. After 10 weeks, Quibitang group showed lower body weight than saline group in CMS-treated groups 3. In open field test, Quibitang group showed significant difference of locomotion, latency. 4. In elevated startIe test, Quibitang group showed no significant change of startle response. 5. In plus maze test, Quibitang group showed no significant change of plus maze-time and plus maze-error.

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