Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Cytotoxic Activity of Vietnamese Herbal Medicines against A549 Cells

A549세포에 대한 베트남 약용식물의 세포독성

  • Cuong, Nguyen Manh (Institute of Chemistry, National Center for Science and Technology) ;
  • Nam, Nguyen-Hai (College of Pharmacy, Chungnam National University) ;
  • Kim, Yong (College of Pharmacy, Chungnam National University) ;
  • You, Young-Jae (College of Pharmacy, Chungnam National University) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Sung, Tran Van (Institute of Chemistry, National Center for Science and Technology) ;
  • Ahn, Byung-Zun (College of Pharmacy, Chungnam National University)
  • Published : 2002.03.30
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Abstract

Eighty methanol extracts prepared from Vietnamese plants were tested for their cytotoxic activity against A549 cells, a human lung carcinoma cell line. Nine extracts showed survival rates of tumor cells of less than 30% at $100\:{\mu}g/mL$ of the methanol extracts. Among them, three were less than 15%; Meliosma pinnata (VK03, 4%), Goniothalamus vietnamensis (VK05, 06, 0%), Garcinia sp. (VK50, 51, 0%) and Aglaia aphanamixis (VK63, 11%). Both leaf and root extracts of Goniothalamus vietnamensis and the leaf extract of a Garcinia species completely inhibited the growth of A549 cells at the concentration of $100\:{\mu}g/mL$ methanol extract.

71종의 베트남 약용식물을 메탄올로 추출하여 얻은 80개의 추출물을 $100\:{\mu}g/mL$의 농도로 조제하여 인체 페암세포인 A549세포에 대한 세포독성을 측정하였다. 9개의 추출물이 30% 이하의 암세포 생존율을 나타내었으며, 이들 중 Meliosma pinnata (VK03, 4%), Goniothalamus vietnamensis (VK05, 06, 0%), Garcinia sp. (VK50, 51, 0%) 그리고 Aglaia aphanamixis (VK63, 11 %)는 15% 이하의 암세포 생존율을 나타내었다. Goniothalamus vietnamensis의 잎과 뿌리 그리고 Garcinia species의 잎의 메탄올 추출물은 $100\:{\mu}g/mL$의 농도에서 암세포의 성장을 100% 억제하였다.

Keywords

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