Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Antithrombotic Effect of Galla Rhois

오배자의 항혈전 효과

  • Song, Gyu-Yong (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Park, Byung-Jun (College of Oriental Medicine, Taejon University) ;
  • Kim, Sung-Hoon (Graduate School of East-West Medical Science, Kyunghee University)
  • 송규용 (경희대학교 동서의학대학원) ;
  • 박병준 (대전대학교 한의과대학) ;
  • 김성훈 (경희대학교 동서의학대학원)
  • Published : 2002.06.30
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Abstract

The possibility of Galla Rhois(GR) water extract as an antithrombotic agent was investigated. The effect of GR on platelet aggregation in human platelet-rich plasma(PRP) induced by collagen and ADP in vitro and coagulation parameters in a pathological model induced by endotoxin and hydrocortisone acetate(HA) in vivo were examined. In platelet aggregation assay, GR extract significantly inhibited platelet aggregation induced by collagen and ADP in a dose-dependent manner. GR extract significantly increased the number of platelet and shortened prothrombin time(PT) and activated thromboplastin time(APTT) as compared with the control in pathological model induced by endotoxin and HA. Also, GR extract significantly increased fibrinogen level as compared with the control in a pathological model induced HA. These results suggest that GR may be a promising antithrombotic agent.

Keywords

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