생약학회지 (Korean Journal of Pharmacognosy)

한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

원추리 지하부의 성분 연구

Constituents from the Roots of Hemerocallis fulva

  • 김주선 (서울대학교 천연물과학연구소) ;
  • 손건호 (안동대학교 식품영양학과) ;
  • 장현욱 (영남대학교 약학대학) ;
  • 김현표 (강원대학교 약학대학) ;
  • 배기환 (충남대학교 약학대학) ;
  • 강삼식 (서울대학교 천연물과학연구소)
  • Kim, Ju-Sun (Natural Products Research Institute, Seoul National University) ;
  • Son, Kun-Ho (Department of Food and Nutrition, Andong National University) ;
  • Chang, Hyeun-Wook (College of Pharmacy, Yeongnam University) ;
  • Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
  • 발행 : 2002.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Besides chrysophanol and friedelin, mixtures of n-hydrocarbons [pentacosane (72.6%), heptacosane (14.6%), tetracosane (5.8%), nonacosane (4.1 %) and hexacosane (2.9%)], n-hydrocarbon alcohols [octacosanol (70.5%) and hexacosanol (29.5%)], l-monoacyl glycerols [acyl part; behenic acid (43.5%), lignoceric acid (32.4%), cerotic acid (9.3%), tricosanoic acid (8.9%), pentacosanoic acid (2.6%), octacosanoic acid (2.3%), heneicosanoic acid (1.0%)], wax esters [behenic acid (56.3%), lignoceric acid (23.0%), cerotic acid (19.8%), tricosanoic acid (4.6%), octacosanoic acid (4.0%), pentacosanoic acid (1.7%), triacontanoic acid (0.6%)/ octacosanol (33.7%), hexacosanol (21.0%), tetracosanol (15.6%), triacontanol (10.5%), docosanol (6.0%), tricosanol (6.0%), heptacosanol (4.2%), nonacosanol (3.0%)] and sterols [${\beta}-sitosterol$ (73.2%), stigmasterol (14.6%), campesterol (12.2%)] were isolated from the roots of Hemerocallis fulva. The acid : alcohol combinations of the major wax esters were $C_{48}$: 22 : 26, 24 : 24, $C_{46}$: 22 : 24, and $C_{44}$: 22 : 22. This is the first report of l-monoacyl glycerols and friedelin from this plant. All isolates were identified on the basis of spectral data and chemical reactions.

키워드

참고문헌

  1. 이창복(1989) 대한식물도감, 201, 향문사, 서울
  2. 배기환(2000) 한국의 약용식물, 534. 교학사,서울
  3. 김재길(1992)원색천연약물대사전(하), 239. 남산당, 서울
  4. 지형준(1998) 한약규격주해(.제2개정), 703. 한국메디칼인 덱스사, 서울
  5. Isono, H., Tachinaim, S. and Kurono, G. (1976) Studies on the Constituents of Liliaceae Plants. V. Convenient Analytical Method on the Consdtuents of Aliphadc Compounds. Yakugaku Zasshi 96: 86-90 https://doi.org/10.1248/yakushi1947.96.1_86
  6. Inoue, T., Iwagoe, K., Konishi, T., Kiyosawa, S. and Fujiwara, Y. (1990) Novel 2,5-dihydroftiry1-\gamma-1actam denvatives from Hemerocallis fulva L. var. kwanzo Regel. Chem. Pharm. Bull. 38: 3187-3189 https://doi.org/10.1248/cpb.38.3187
  7. Inoue, T., Konishi, T., Kiyosawa, S. and Fujiwara, Y. (1994) 2,5-Dihydrofury1-\gamma-1actam derivatives from Hemerocallis fulva L. var. kwanzo Regel. II. Chem. Pharm. Bull. 42: 154- 155 https://doi.org/10.1248/cpb.42.154
  8. Konishi, T., Fujiwara, Y, Konoshima, T, Kiyosawa, S., Nishi, M. and Miyahara, K. (2001) Steroidal saponins from Hemerocallis fulva var. kwanzo. Chem. Pharm. Butt. 49: 318-320 https://doi.org/10.1248/cpb.49.318
  9. Sarg, T. M., Salem, S. A., Farrag, N. M., Abdel-Aal, M. M. and Ateya, A. M. (1990) Phytochemical and Andmicrobial Investigation of Hemerocallis fulva L. grown in Egypt. Int. J. Crude Drug Res. 28: 153-156 https://doi.org/10.3109/13880209009082803
  10. Hsieh, M.-T., Ho, Y.-R., Peng, W.-H., Wu, C.-R. and Chen, C.-F. (1996) Effects of Hemerocallis flava on motor acdvityand the concentration of central monoamines and its metabolites in rats. J. Ethnopharmacol. 52: 71-76 https://doi.org/10.1016/0378-8741(96)01388-8
  11. Hata, K., Ishikawa, K. and Hoii, K. (1998) Differendadon-inducing activities of human leukemia cell line (HL60) by extracts of edible wild plants in Akita. NaturaI Medicines 52: 269-272
  12. Gaver, R. C. and Sweeley, C. C. (1965) Methods for methanolysis of sphingolipids and direct determination of long-chain bases by gas chromatography. J. Am. Oil Chemist's Soc. 42: 294-298 https://doi.org/10.1007/BF02540132
  13. Kitajima, J., Mukai, A., Masuda, Y. and Tanaka, Y. (1989) Studies on the constituents of Tnchosanthes root. III. Constituents of roots of Trichosanthes bracteata Voigt. Yakugaku Zasshi 109: 265-270 https://doi.org/10.1248/yakushi1947.109.4_265
  14. Herbin, G. A. and Robins, P. A. (1968) Studies on Plant Cudcular Waxes-III. The Leaf Wax alkanes and co-Hydroxy Acids of Some Members of The Cupressaceae and Pinaceae. Phytochemistry 7: 1325-1337 https://doi.org/10.1016/S0031-9422(00)85633-2
  15. Lin, C. N., Chung, M. I. and Lu, C. M. (1990) Anthraquinones from Rhamnus formosana. Phytochemistry 29: 3903-3905 https://doi.org/10.1016/0031-9422(90)85356-K
  16. Klass, J., Tinto, W. R, Mclean, S. and Reynolds, W. P. (1992) Friedelane Tnterpenoids from Peritassa compta; Complete \{^1}H and \{^1^3}C Assigmnents by 2D NMR Spectroscopy. J. Nat. Prod. 55: 1626-1630 https://doi.org/10.1021/np50089a010
  17. Takemoto, T. and Kusano, G. (1966) Studies on the Constituents of Hemerocallis. I. Constituents of Hemerocallis toneituba. Yakueaku Zasshi 86: 1116-1119 https://doi.org/10.1248/yakushi1947.86.11_1116