Korean Journal of Oriental Medicine (한국한의학연구원논문집)

Korean Institute of Oriental Medicine (한국한의학연구원)
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Inhibitive Effect of KH against Toxicity Induced by 5-Flurouracil(FU)

화학요법제 5-flurouracil의 조혈 및 면역독성 억제를 위한 조성물 개발 연구

  • Yang, Dong-Sik (Dept of Medical R&D, Korea Institute of Oriental Medicine) ;
  • Hong, Min-Young (Dept of Medical R&D, Korea Institute of Oriental Medicine) ;
  • Sung, Hyun-Jea (Oriental Medical School, Semyung University) ;
  • Yoon, Yoo-Sik (Dept of Medical R&D, Korea Institute of Oriental Medicine)
  • 양동식 (한국한의학연구원 의료연구부) ;
  • 홍민영 (한국한의학연구원 의료연구부) ;
  • 성현제 (세명대학교 한의과대학) ;
  • 윤유식 (한국한의학연구원 의료연구부)
  • Published : 2002.12.31
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Abstract

The objective on this study was to investigate effect of KH, which was composed of 9 kinds of oriental herbs tonifing the blood, against toxicity of 5-flurouracil(FU) through animal study. Reduction of WBC and platelet after treating S-FU was significantly recovered by KH. KH also rehabilitated immune gene expression of interleukin-2(IL2) and $Interferon-{\gamma}\;(IFN-{\gamma})$ by RT-PCR. In addition, in situ hybridization of spleen showed that KH treatment increased mRNA expression of IL2. In addition to the immune action, antitumor activity on 5-FU was not affected by KH treatment. In conclusion, our study demonstrated that KH alleviated damage of hematopoiesis system induced by f-FU without toss of antitumor activity.

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