Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
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Effect of Hot Water Extract from Acanthopanax senticosus on Systemic Anaphylaxis

가시오가피 열수추출물의 전신성 Anaphylaxis에 대한 억제효과

  • Yoon, Taek-Joon (Department of Food Science and Biotechnology, Kyonggi University) ;
  • Lee, Seok-Won (Department of Oncology, Graduate School of E-W Medical Science, KyungHee University) ;
  • Shin, Kwang-Soon (Department of Food Science and Biotechnology, Kyonggi University) ;
  • Choi, Won-Hee (Research & Development Team, GooFoo Inc) ;
  • Hwang, Soo-Hyun (Department of Food Science and Biotechnology, Kyonggi University) ;
  • Seo, Sang-Hee (Research & Development Team, GooFoo Inc) ;
  • Kim, Sung-Hoon (Department of Oncology, Graduate School of E-W Medical Science, KyungHee University) ;
  • Park, Woo-Mun (Research & Development Team, GooFoo Inc)
  • Published : 2002.06.01
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Abstract

Administration of hot water extracts from Acanthopanax senticosus (GF-2) prophylactically and therapeutically inhibited the systemic anaphylactic shock induced by compound 48/80 in mouse. GF-2 significantly inhibited the production of histamine and eosinophyl in mouse serum through the injection of compound 48/80 in a dose-dependent manner. GF-2 inhibited dose dependently $TNF-{\alpha}$ production of peritoneal exudative cells activated by lipopolysaccharide. Intraperitoneal injection of GF-2 suppressed the production of IgG1 and IgE antibodies in mice immunized with a mixture of ovalbumin and aluminium hydroxide. These results suggest that GF-2 may be beneficial for the treatment of nonspecific and specific anaphylactic reactions and can be potentially applied to the treatment of allergic diseases.

마우스에서 가시오가피 열수추출물(GF-2)의 투여는 compound 48/80에 의하여 유도되는 전신성 anaphylactic shock 및 혈중 histamine과 호산구의 생산을 GF-2 농도 의존적으로 억제하였을 뿐 아니라, 마우스 복강세포에서 LPS에 의하여 유도되는 $TNF-{\alpha}$의 생산을 유의적으로 감소시켰다. 또한, 마우스에 항원으로서 ovalbumin(OVA)와 adjuvant로서 aluminium hydroxide를 사용하여 면역 후, OVA에 대한 IgG1 및 IgE 항체의 역가를 조사한 결과, GF-2의 투여는 이들 항체의 생산을 억제하였다. 이 결과는 GF-2를 항원 특이적 혹은 비특이적인 알러지 반응에 응용할 수 있는 소재로 개발 가능성 있음을 제시하였다.

Keywords

References

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