Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Inhibitory Effects of the Extract of Rhus verniciflua Stokes on the Reverse Transcriptase of AIDS

  • Kim, Myong-Jo (College of Agricultural and Life Science, Kangwon National University) ;
  • Choi, Won-Cheol (Kwanghyeowon Mediacal Foundation Cancer Center) ;
  • Barshinikov, A. M. (Russian N. N., Blocklhin Cancer Center) ;
  • Kobayashi, A. (Osaka National University)
  • Published : 2002.11.30
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Abstract

Four olefinic catechols, commonly referred to as urushiol were isolated from the sap of Korean Rhus verniciflua Stokes and had the stronger inhibitory effects on the reverse transcriptase of AIDS. The hexane extract with a inhibitory effects on reverse transcriptase was purified by silica and ODS gel column chromatography. The active compounds were identified by MS and $^1H-NMR$ as 3-[8' (Z), 11' (Z), 14' -pentadecatrienyl]catechol, 3-[8' (Z), 11' (Z)-pentadecadienyl]catechol, 3-[8' (Z)-penta- decenyl]catechol, and 3-pentadecylcatechol. All of these compounds showed strong inhibitory effects on reverse transcriptase of AIDS, in which 3-pentadecylcatechol exhibited the highest activity $(IC_{50}\;:\;10.87\;{\mu}g/ml)$.

Keywords

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